公开(公告)号：US20060216740A1

公开(公告)日：2006-09-28

申请号：US11401713

申请日：2006-04-11

申请人： Carl Edman ,  Michael Heller ,  Rachel Formosa ,  Christian Gurtner

发明人： Carl Edman ,  Michael Heller ,  Rachel Formosa ,  Christian Gurtner

IPC分类号： C12Q1/68

CPC分类号： H01L24/95 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00536 ,  B01J2219/00545 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00614 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00707 ,  B01J2219/00711 ,  B01J2219/00713 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L9/52 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2400/0418 ,  B82B3/00 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C07B2200/11 ,  C07H21/00 ,  C07K1/04 ,  C07K1/045 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  C40B70/00 ,  G01N33/54366 ,  G02B6/1225 ,  G06N3/002 ,  G06N3/061 ,  G06N3/123 ,  G11B7/00455 ,  G11B7/0052 ,  G11B7/244 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/04 ,  G11C19/00 ,  H01L25/50 ,  H01L29/6656 ,  H01L29/6659 ,  H01L29/66628 ,  H01L29/7834 ,  H01L51/0093 ,  H01L51/0595 ,  H01L2224/95085 ,  H01L2224/95145 ,  H01L2224/95147 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01011 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01018 ,  H01L2924/01019 ,  H01L2924/0102 ,  H01L2924/01023 ,  H01L2924/01027 ,  H01L2924/01033 ,  H01L2924/01039 ,  H01L2924/01044 ,  H01L2924/01047 ,  H01L2924/01049 ,  H01L2924/01052 ,  H01L2924/01072 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01322 ,  H01L2924/014 ,  H01L2924/10253 ,  H01L2924/10329 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/30105 ,  H01L2924/3025 ,  H01L2924/00

摘要： Methods are provided for the fabrication of microscale, including micron and sub-micron scale, including nanoscale, devices. Electronic transport of movable component devices is utilized through a fluidic medium to effect transport to a desired target location on a substrate or motherboard. Forces include electrophoretic force, electroosmotic force, electrostatic force and/or dielectrophoretic force. In the preferred embodiment, free field electroosmotic forces are utilized either alone, or in conjunction with, other forces. These forces may be used singly or in combination, as well as in conjunction with yet other forces, such as fluidic forces, mechanical forces or thermal convective forces. Transport may be effected through the use of driving electrodes so as to transport the component device to yet other connection electrodes. In certain embodiments, the component devices may be attached to the target device using a solder reflow step.

摘要翻译： 提供了用于制造微尺寸的方法，包括微米级和亚微米级，包括纳米尺度的器件。 通过流体介质利用可移动部件装置的电子传输，以实现传输到基板或主板上的期望的目标位置。 力包括电泳力，电渗力，静电力和/或介电泳力。 在优选实施例中，自由场电渗力单独使用或与其它力结合使用。 这些力可以单独使用或组合使用，以及结合其他力，例如流体力，机械力或热对流力。 传输可以通过使用驱动电极来实现，以便将组件设备传送到另外的连接电极。 在某些实施例中，组件装置可以使用焊料回流步骤连接到目标装置。

公开(公告)号：US20050026202A1

公开(公告)日：2005-02-03

申请号：US10925375

申请日：2004-08-23

申请人： Carl Edman ,  Eugene Tu ,  Christian Gurtner ,  Lorelei Westin ,  Michael Heller

发明人： Carl Edman ,  Eugene Tu ,  Christian Gurtner ,  Lorelei Westin ,  Michael Heller

IPC分类号： B01J19/00 ,  B01L3/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/551 ,  C12Q1/68 ,  C12M1/34 ,  H03C1/00

CPC分类号： B82Y30/00 ,  B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00621 ,  B01J2219/0063 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00713 ,  B01J2219/0072 ,  B01J2219/0074 ,  B01L3/502753 ,  B01L2300/0819 ,  B01L2400/0415 ,  G01N33/5308 ,  G01N33/54353 ,  G01N33/5438 ,  G01N33/551 ,  Y10S977/924

摘要： This invention pertains to the design, fabrication, and uses of an electronic system which can actively carry out and control multi-step and multiplex reactions in macroscopic or microscopic formats. In particular, these reactions include molecular biological reactions, such as nucleic acid hybridizations, nucleic acid amplification, sample preparation, antibody/antigen reactions, clinical diagnostics, combinatorial chemistry and selection, drug screening, oligonucleotide and nucleic acid synthesis, peptide synthesis, biopolymer synthesis, and catalytic reactions. A key feature of the present invention is the ability to control the localized concentration of two or more reaction-dependant molecules and their reaction environment in order to greatly enhance the rate and specificity of the molecular biological reaction

摘要翻译： 本发明涉及电子系统的设计，制造和使用，其可以以宏观或微观格式主动地执行和控制多步和多重反应。 特别地，这些反应包括分子生物反应，例如核酸杂交，核酸扩增，样品制备，抗体/抗原反应，临床诊断，组合化学和选择，药物筛选，寡核苷酸和核酸合成，肽合成，生物聚合物合成 ，和催化反应。 本发明的一个关键特征是控制两种或多种反应依赖性分子及其反应环境的局部浓度的能力，以便大大提高分子生物反应的速率和特异性

公开(公告)号：US20070178516A1

公开(公告)日：2007-08-02

申请号：US11726520

申请日：2007-03-22

申请人： Ronald Sosnowski ,  William Butler ,  Eugene Tu ,  Michael Nerenberg ,  Michael Heller ,  Carl Edman

发明人： Ronald Sosnowski ,  William Butler ,  Eugene Tu ,  Michael Nerenberg ,  Michael Heller ,  Carl Edman

IPC分类号： C12Q1/68

CPC分类号： H01L29/7834 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00713 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502761 ,  B01L3/5085 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2400/0415 ,  B01L2400/0421 ,  B82Y5/00 ,  B82Y10/00 ,  C07B2200/11 ,  C07H21/00 ,  C07K1/04 ,  C07K1/045 ,  C07K1/047 ,  C12Q1/6825 ,  C12Q1/6832 ,  C12Q1/6837 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/04 ,  G11C19/00 ,  H01L25/50 ,  H01L29/6656 ,  H01L29/6659 ,  H01L29/66628 ,  H01L2224/95145 ,  H01L2224/95147 ,  H01L2924/01019 ,  H01L2924/01025 ,  H01L2924/01046 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/10253 ,  C12Q2565/515 ,  C12Q2565/607 ,  H01L2924/00

摘要： A method for electronically stabilizing hybridization of nucleic acids bound at a test site of a microelectronic device is described. First and second negatively charged nucleic acids are provided, the second nucleic acid being bound to the test site. A zwitterionic buffer having a conductance of less than 100 mS/cm is applied to the microelectronic device. A current is applied to the test site to positively bias the test site, such that the first negatively charged nucleic acid is transported to the positively biased test site having the bound the second negatively charged nucleic acid. At the test site, the first and second negatively charged nucleic acids hybridize. The zwitterionic buffer acquires a net positive charge under influence of the current, such that the positively charged zwitterionic buffer stabilizes the hybridization by reducing the repulsion between the first and second negatively charged nucleic acids

摘要翻译： 描述了用于电子稳定在微电子器件的测试位点处结合的核酸杂交的方法。 提供第一和第二带负电荷的核酸，第二核酸与测试部位结合。 将具有小于100mS / cm 2的电导的两性离子缓冲液施加到微电子器件。 将电流施加到测试部位以使测试部位正偏置，使得将第一带负电荷的核酸转运到具有结合第二带负电荷核酸的正偏压测试位点。 在测试位点，第一和第二带负电荷的核酸杂交。 两性离子缓冲液在电流影响下获得净正电荷，使得带正电的两性离子缓冲液通过降低第一和第二带负电的核酸之间的排斥来稳定杂交

公开(公告)号：US20060253005A1

公开(公告)日：2006-11-09

申请号：US11402225

申请日：2006-04-11

申请人： Darrel Drinan ,  Carl Edman ,  Diethard Merz

发明人： Darrel Drinan ,  Carl Edman ,  Diethard Merz

IPC分类号： A61B5/00 ,  A61M31/00 ,  A61M5/32

CPC分类号： A61B5/0002 ,  A61B5/0022 ,  A61B5/02 ,  A61B5/04 ,  A61B5/08 ,  A61B5/082 ,  A61B5/145 ,  A61B5/14539 ,  A61B5/411 ,  A61B5/4839 ,  A61B5/486 ,  A61B2560/0271 ,  A61M5/14276 ,  A61M2005/1726 ,  A61M2205/3523 ,  A61M2205/3569 ,  G06F19/3418 ,  G16H10/60 ,  G16H40/63 ,  Y02A90/22 ,  Y02A90/26 ,  Y10S128/903 ,  Y10S128/904

摘要： The invention relates to methods and devices for remote or distributed continuous monitoring of physiologically relevant states. The invention provides for methods to automatically detect deviations or other states in physiological parameters and automatically alert a measured subject, user or other authorized party. The device provides for a universal platform for sensors, and further provides for the automatic compensation or distribution of devices or bioactive agents at appropriate levels and/or intervals in response to deviations or other states sensed in various physiological parameters.

公开(公告)号：US20060110754A1

公开(公告)日：2006-05-25

申请号：US11251229

申请日：2005-10-14

申请人： Michael Nerenberg ,  Carl Edman ,  Catherine Spargo ,  George Walker

发明人： Michael Nerenberg ,  Carl Edman ,  Catherine Spargo ,  George Walker

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M1/34

CPC分类号： C12Q1/6844 ,  C12P19/34 ,  C12Q1/6825 ,  C12Q1/6837 ,  C12Q2537/143 ,  C12Q2531/119 ,  C12Q2565/501 ,  C12Q2565/607

摘要： Described and disclosed are devices, methods, and compositions of matter for the multiplex amplification and analysis of nucleic acid sequences in a sample using novel strand displacement amplification technologies in combination with bioelectronic microchip technology. Specifically, a nucleic acid in a sample is amplified to form amplicons, the amplicons are addressed to specified electronically addressable capture sites of the bioelectronic microchip, the addressed amplicons are captured and labeled, and then the capture sites are analyzed for the presence of label. Samples may be amplified using strand displacement amplification. The invention is also amenable to other amplification methodologies well known by those skilled in the art. The capture and label steps may be by a method of universal capture with sequence specific reporter, or by a method of sequence specific capture with universal reporter. The label may be detected by fluorescence, chemiluminescence, elecrochemiluminescence, or any other technique as are well known by those skilled in the art. This invention further allows for analyzing multiple nucleic acid targets on a single diagnostic platform wherein the nucleic acids may be amplified while either in direct contact with microchip components or in solution above the microchip array.

公开(公告)号：US20060058593A1

公开(公告)日：2006-03-16

申请号：US11219327

申请日：2005-09-02

申请人： Darrel Drinan ,  Carl Edman

发明人： Darrel Drinan ,  Carl Edman

IPC分类号： A61B5/00

CPC分类号： A61B5/6807 ,  A61B5/0022 ,  A61B5/0531 ,  A61B5/0537 ,  A61B5/441 ,  A61B5/445 ,  A61B5/447 ,  A61B5/6804 ,  A61B5/6831 ,  A61B5/685 ,  A61B2560/0412 ,  A61B2562/08 ,  A61B2562/164 ,  Y02A90/26

摘要： Systems and techniques are provided for monitoring hydration. In one implementation, a method includes measuring an electrical impedance of a region of a subject to generate an impedance measurement result. The result may be correlated with a blood loss condition.

摘要翻译： 提供了用于监测水合作用的系统和技术。 在一个实施方式中，一种方法包括测量受试者的区域的电阻抗以产生阻抗测量结果。 结果可能与失血状况相关。

公开(公告)号：US20050203637A1

公开(公告)日：2005-09-15

申请号：US10984681

申请日：2004-11-08

申请人： Carl Edman ,  Darrel Drinan

发明人： Carl Edman ,  Darrel Drinan

IPC分类号： A61B20060101 ,  A61F2/00 ,  A61F2/02 ,  A61M31/00 ,  B23K26/36 ,  C25D5/48

CPC分类号： A61F2/0077 ,  A61F2250/0067 ,  A61M31/002 ,  A61M2025/006

摘要： A structure for and method of manufacture of structures for implantation within the tissue of a mammalian subject are disclosed. These structures can be utilized in applications such as the delivery of therapeutic drugs to the tissue of the subject or the sampling of biofluids for the purposes of diagnosis. In one embodiment of the invention, a rigid structure has defined ingrowth features on a surface intended to contact tissue of the subject and defined passage features which provide a fluid path from the surface intended to contact tissue to another surface. The dimensions of these defined features vary based on the particular application, as the ingrowth features are of a dimension and spacing to promote ingrowth of the surrounding tissue, and the passage features are of a dimension to inhibit the passage through the structure of cells from the surrounding tissue.

摘要翻译： 公开了用于植入哺乳动物受试者组织内的结构的结构和制造方法。 这些结构可以用于诸如将治疗药物递送到受试者的组织或用于诊断目的的生物流体取样的应用中。 在本发明的一个实施例中，刚性结构在旨在接触受试者的组织的表面上具有限定的向内生长特征，并且具有限定的通道特征，其提供从旨在接触组织的表面到另一表面的流体路径。 这些限定特征的尺寸基于特定应用而变化，因为向内生长特征具有维度和间隔以促进周围组织的向内生长，并且通道特征具有一定的尺寸，以阻止细胞结构从 周围组织。

公开(公告)号：US20050197654A1

公开(公告)日：2005-09-08

申请号：US11009548

申请日：2004-12-09

申请人： Carl Edman ,  Darrel Drinan ,  Robert Lackey

发明人： Carl Edman ,  Darrel Drinan ,  Robert Lackey

IPC分类号： A61J15/00 ,  A61K9/00 ,  A61K9/22 ,  A61M20060101 ,  A61M5/142 ,  A61M31/00 ,  A61M39/02

CPC分类号： A61K9/0019 ,  A61B5/076 ,  A61B5/4839 ,  A61J15/00 ,  A61K9/0009 ,  A61M5/14244 ,  A61M39/0247 ,  A61M2005/14268 ,  A61M2039/0205 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61M2205/3569

摘要： The invention relates to a parenteral therapeutic agent delivery device. The therapeutic agent delivery device has a disposable section and an implant section suitable for long term implantation within the tissue of a subject. When necessary, the disposable section can be detached from the implant section, and a new disposable section can be attached. The disposable section may contain a reservoir containing the therapeutic agent, a pump for dispensing the therapeutic agent, controlling circuitry for regulating the dispensing of the therapeutic agent, and transceiver circuitry and an antenna for wireless communication with external devices.

摘要翻译： 本发明涉及一种胃肠外治疗剂递送装置。 治疗剂递送装置具有适于长期植入受试者组织内的一次性部分和植入部分。 必要时，一次性部分可以从植入部分分离，并且可以附接新的一次性部分。 一次性部分可以包含容纳治疗剂的储存器，用于分配治疗剂的泵，用于调节治疗剂的分配的控制电路，以及收发器电路和用于与外部装置的无线通信的天线。

公开(公告)号：US20080039718A1

公开(公告)日：2008-02-14

申请号：US11837357

申请日：2007-08-10

申请人： Darrel Drinan ,  Carl Edman ,  Naresh Bhavaraju

发明人： Darrel Drinan ,  Carl Edman ,  Naresh Bhavaraju

IPC分类号： A61B5/055

CPC分类号： A61B5/05 ,  A61B5/0002 ,  A61B5/0507 ,  A61B5/1075 ,  A61B5/413 ,  A61B8/08

摘要： Aspects include methods and apparatuses for determining change over time in one or more measured regions of a body using a plurality of data sets obtained by analysis of applied signals to said region. The method may include transmitting and receiving one or more of electromagnetic wave signals, applied acoustic wave signals and electrical signals transmitted through or reflected off of a portion of the measured body region.

摘要翻译： 方面包括使用通过分析所施加的信号到所述区域获得的多个数据集来确定身体的一个或多个测量区域中随时间变化的方法和装置。 所述方法可以包括发射和接收一个或多个电磁波信号，施加的声波信号以及通过测量的身体区域的一部分透射或反射的电信号。

公开(公告)号：US20070141164A1

公开(公告)日：2007-06-21

申请号：US11670061

申请日：2007-02-01

申请人： Soonkap Hahn ,  Roberto Fagnani ,  Xiaofan Dong ,  Carl Edman ,  Pavel Tsinberg

发明人： Soonkap Hahn ,  Roberto Fagnani ,  Xiaofan Dong ,  Carl Edman ,  Pavel Tsinberg

IPC分类号： A61K9/50 ,  C08F283/04 ,  B01J13/02

CPC分类号： G01N33/5436 ,  A61K9/1641 ,  B01J19/0046 ,  B01J2219/00367 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01J2219/00743 ,  B82Y30/00 ,  C08G18/10 ,  C08G65/33348 ,  C08G65/3342 ,  C08G2210/00 ,  C08L2203/02 ,  C12N11/04 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  C08G18/3876

摘要： A method for encapsulating biologics within a hydrogel by using an aqueous solution of an isocyanate-functional polyurethane prepolymer which is mixed with an amount of biologics and an aqueous solution containing a dithiol crosslinking agent under physiological pH conditions to create a hydrogel. An additional bidentate crosslinking agent is optionally included. The product of such method may be a bioreactor or an assay device having a plurality of different biologics encapsulated at predetermined locations in a substrate.

摘要翻译： 一种通过使用异氰酸酯官能的聚氨酯预聚物的水溶液将生物制剂包封在水凝胶内的方法，其在生理pH条件下与一定数量的生物制剂和含有二硫醇交联剂的水溶液混合以产生水凝胶。 任选地包括另外的二齿交联剂。 这种方法的产物可以是生物反应器或具有封装在基底中的预定位置处的多种不同生物制剂的测定装置。