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公开(公告)号：US20160346748A1
公开(公告)日：2016-12-01
申请号：US15171616
申请日：2016-06-02
Applicant: Raindance Technologies, Inc.
Inventor： Yevgeny Yurkovetsky , Darren R. Link , Jonathan William Larson
CPC classification number: B01F13/0076 , B01F3/0803 , B01F3/0865 , B01F5/0085 , B01F5/0471 , B01F5/0473 , B01F13/0062 , B01F13/0071 , B01F2215/0037 , B01L3/502784 , B01L7/525 , B01L2200/0652 , B01L2200/0673 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487
Abstract: The invention generally relates to methods for forming mixed droplets. In certain embodiments, methods of the invention involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet.
Abstract translation: 本发明一般涉及用于形成混合液滴的方法。 在某些实施方案中，本发明的方法包括形成液滴并使液滴与流体流接触，其中流体流的一部分与液滴形成混合液滴。
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公开(公告)号：US09494520B2
公开(公告)日：2016-11-15
申请号：US13866141
申请日：2013-04-19
Applicant: Raindance Technologies, Inc.
Inventor： Darren R. Link
CPC classification number: G01N21/6486 , B01L3/502784 , C12Q1/686 , G01N15/1434 , G01N15/1459 , G01N15/1484 , C12Q2565/629
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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公开(公告)号：US20140303005A1
公开(公告)日：2014-10-09
申请号：US14245348
申请日：2014-04-04
Applicant: Raindance Technologies, Inc.
Inventor： Michael Samuels , Darren R. Link
IPC: C12N15/10
CPC classification number: C12N15/1075 , C12Q1/6806 , C12Q2563/159
Abstract: The invention generally relates to rare cell analysis after negative selection.
Abstract translation: 本发明一般涉及阴性选择后的稀有细胞分析。
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公开(公告)号：US20160289670A1
公开(公告)日：2016-10-06
申请号：US14874553
申请日：2015-10-05
Applicant: Raindance Technologies, Inc.
Inventor： Michael Samuels , Jeffrey Charles Olson , Andrew Watson , Keith Brown , Darren R. Link
IPC: C12N15/10 , G01N33/543
CPC classification number: C12N15/1075 , C12Q1/6874 , C40B50/08 , G01N33/5436 , G01N33/58
Abstract: The invention provides barcode libraries and methods of making and using them including obtaining a plurality of nucleic acid constructs in which each construct comprises a unique N-mer and a functional N-mer and segregating the constructs into a fluid compartments such that each compartment contains one or more copies of a unique construct. The invention further provides methods for digital PCR and for use of barcode libraries in digital PCR.
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25.发明授权Microfluidic devices and methods of use in the formation and control of nanoreactors 有权微流体装置和用于形成和控制纳米反应器的方法公开(公告)号：US09410151B2
公开(公告)日：2016-08-09
申请号：US14226482
申请日：2014-03-26
Applicant: Raindance Technologies, Inc.
Inventor： Darren R. Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
IPC: C12Q1/68 , C12N15/10 , B01F13/00 , B01J19/00 , B82Y5/00 , B82Y30/00 , C07K1/04 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N33/536 , G01N33/68 , G01N33/543 , C12M1/34 , B01L3/00 , B01F3/08 , B01L7/00
CPC classification number: C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.
Abstract translation: 本发明提供了可用于进行高通量筛选测定和组合化学的新型微流体装置和方法。 本发明提供了含有唯一标记的细胞，酶，核酸等的含水基乳液，其中乳液还包含引物，标记，探针和其它反应物。 油基载体流体在微流体装置上包封乳剂库，使得连续通道提供不混溶流体的流动，以实现乳液库的汇集，聚结，混合，分选，检测等。
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Patent Agency Ranking
公开(公告)号：US09341594B2
公开(公告)日：2016-05-17
申请号：US14511892
申请日：2014-10-10
Applicant: Raindance Technologies, Inc.
Inventor： Benjamin J. Miller , Brian Hutchison , Andrew Wilson , Jonathan William Larson , Qun Zhong , Yevgeny Yurkovetsky , Darren R. Link , Mark Weary
IPC: B01L3/02 , G01N27/447 , B01L3/00 , F17D3/01 , G01N21/03
CPC classification number: G01N1/38 , B01L3/0241 , B01L3/502715 , B01L3/502784 , B01L2200/061 , B01L2200/0673 , B01L2200/143 , B01L2300/0877 , F16K99/0001 , F16K2099/0084 , F17D3/01 , G01N27/44791 , G01N2021/0353 , Y10T137/2185 , Y10T137/7761 , Y10T137/8158 , Y10T137/8593 , Y10T436/118339
Abstract: The invention provides methods for assessing one or more predetermined characteristics or properties of a microfluidic droplet within a microfluidic channel, and regulating one or more fluid flow rates within that channel to selectively alter the predetermined microdroplet characteristic or property using a feedback control.
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公开(公告)号：US09273308B2
公开(公告)日：2016-03-01
申请号：US13629227
申请日：2012-09-27
Applicant: RainDance Technologies, Inc.
Inventor： Darren R. Link , Michael Weiner , David Marran , Jonathan M. Rothberg
IPC: G01N1/10 , B01L3/00 , B01L3/02 , C12N15/10 , B01F3/08 , B01F13/00 , B01J19/00 , B03C5/00 , B03C5/02 , C12Q1/00 , C12Q1/68 , G01N15/14 , G01N21/05 , G01N21/64 , G01N35/08 , G01N27/327 , B01L7/00 , B01L9/00 , G01N35/00 , G01N21/03
CPC classification number: B01F3/0807 , B01F13/0062 , B01J19/0093 , B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/565 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/086 , B03C5/005 , B03C5/026 , C12N15/1068 , C12N15/1086 , C12Q1/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6844 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/628 , C12Q2565/629 , G01N15/147 , G01N21/05 , G01N21/64 , G01N27/3275 , G01N35/08 , G01N2021/0346 , G01N2035/00237 , G01N2035/00326 , G01N2201/024 , Y10T137/87571 , Y10T137/87619 , Y10T137/87652 , C12Q2525/191 , C12Q2563/159 , C12Q2535/101 , C12Q2563/149 , C12Q2531/113
Abstract: The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.
Abstract translation: 本发明提供了可用于进行生物学，化学和诊断测定的新型微流体底物和方法。 基板可以包括多个可电寻址的通道支承流体模块，其一体地布置成使得提供用于不混溶流体流动的连续通道。
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公开(公告)号：US09228229B2
公开(公告)日：2016-01-05
申请号：US13796901
申请日：2013-03-12
Applicant: Raindance Technologies, Inc.
Inventor： Jeffrey Olson , Darren R. Link
CPC classification number: C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6883 , C12Q1/6886 , C12Q2600/172 , C12Q2563/159 , C12Q2565/629 , C12Q2537/143 , C12Q2531/113 , C12Q2535/131
Abstract: The invention generally relates to droplet based digital PCR and methods for analyzing a target nucleic acid using the same. In certain embodiments, methods of the invention involve forming sample droplets containing, on average, a single target nucleic acid, amplifying the target in the droplets, excluding droplets containing amplicon from the target and amplicon from a variant of the target, and analyzing target amplicons.
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29.发明申请MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS 有权微流体装置及其在纳米复合材料的形成与控制中的应用公开(公告)号：US20140323317A1
公开(公告)日：2014-10-30
申请号：US14248991
申请日：2014-04-09
Applicant: Raindance Technologies, Inc.
Inventor： Darren R. Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
CPC classification number: C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
Abstract: The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.
Abstract translation: 本发明提供了可用于进行高通量筛选测定和组合化学的新型微流体装置和方法。 本发明提供了含有唯一标记的细胞，酶，核酸等的含水基乳液，其中乳液还包含引物，标记，探针和其它反应物。 油基载体流体在微流体装置上包封乳剂库，使得连续通道提供不混溶流体的流动，以实现乳液库的汇集，聚结，混合，分选，检测等。
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公开(公告)号：US20140256568A1
公开(公告)日：2014-09-11
申请号：US14281212
申请日：2014-05-19
Applicant: Raindance Technologies, Inc.
Inventor： Darren R. Link
CPC classification number: C12Q1/6874 , C12N15/1068 , C12Q1/686 , C12Q2537/143 , C12Q2563/185
Abstract: The invention generally relates to methods for sample multiplexing. In certain embodiments, methods of the invention obtaining a plurality of different reactant molecules, attaching a unique identifier to the reactant molecules, and forming a droplet including the reactant molecules.
Abstract translation: 本发明一般涉及用于样本多路复用的方法。 在某些实施方案中，本发明的方法获得多种不同的反应物分子，将唯一标识符附着到反应物分子上，以及形成包含反应物分子的液滴。
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