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公开(公告)号：US20180086896A1
公开(公告)日：2018-03-29
申请号：US15716500
申请日：2017-09-26
发明人： Eric A. Appel
IPC分类号： C08K3/36 , C09K21/02 , C09K21/14 , A61L27/02 , A61L27/20 , A61L27/52 , A01N25/10 , A61K9/06 , A61K47/38 , A61K47/02 , A01N25/04 , B08B9/032
CPC分类号： C08K3/36 , A01N25/04 , A01N25/10 , A61K9/06 , A61K47/02 , A61K47/38 , A61L27/025 , A61L27/20 , A61L27/52 , A61L2400/12 , B08B9/0321 , C08K2201/011 , C08L1/28 , C08L1/284 , C08L2666/58 , C09K21/02 , C09K21/14
摘要： The present invention provides moldable, fully scalable cellulose silica-based hydrogels for use as low-cost and safe carriers and aqueous viscosity modifiers in various industrial and medical applications.
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公开(公告)号：US20180085496A1
公开(公告)日：2018-03-29
申请号：US15563382
申请日：2016-03-31
申请人： Yale University
发明人： Tarek Fahmy , Albert Sinusas , Jung Seok Lee , Dongin Kim
IPC分类号： A61L31/02 , A61K49/12 , A61L27/52 , A61L27/04 , A61L27/54 , A61L31/16 , A61L31/14 , A61L27/44 , A61L31/12 , A61L27/18 , A61L31/06 , A61L27/20 , A61L31/04 , A61L27/58 , A61L27/34 , A61L27/30 , A61L31/10 , A61L31/08
CPC分类号： A61L31/022 , A61K49/126 , A61L24/0073 , A61L24/02 , A61L27/04 , A61L27/042 , A61L27/06 , A61L27/18 , A61L27/20 , A61L27/306 , A61L27/34 , A61L27/44 , A61L27/446 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/028 , A61L31/042 , A61L31/06 , A61L31/088 , A61L31/10 , A61L31/125 , A61L31/128 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2400/12 , A61L2420/02
摘要： It has been discovered that iron-platinum magnetic particles can be dispersed in a polymer and coated into or onto, or directly linked to, polymeric materials, especially hydrogels, and magnetized. The magnetized materials are used to attract, capture, and/or retain magnetically labeled cells in the material in vivo. The magnetic particles have an iron/platinum core. Annealing the Fe:Pt is very important for introducing a crystal structure LIO interior crystalline phase. The Fe:Pt molar ratio for creation of the crystal phase is important and a molar range of 1.2-3.0 Fe to Pt (molar precursors, i.e starting compounds) is desired for magnetization. The magnetic force as a whole can be measured with a “Super Conducting Quantum Interference Scaffold”, which is a sensitive magnetometer. The overall magnetic force is in the range from 0.1 to 2.0 Tesla.
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公开(公告)号：US20180085492A1
公开(公告)日：2018-03-29
申请号：US15720403
申请日：2017-09-29
发明人： Guillermo A. Ameer , Xunrong Luo , Xiaomin Zhang , Yunxiao Zhu
CPC分类号： A61L27/3804 , A61L27/16 , A61L27/18 , A61L27/34 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/43 , A61L2300/602 , A61L2300/64 , C08L71/02 , C08L33/26
摘要： Provided herein are thermoresponsive citrate-based hydrogels and methods of use thereof for cell delivery. In particular, pancreatic islet cells entrapped within poly(polyethyleneglycol citrate-co-N isopropylacrylamide) (PPCN) hydrogels are provided herein, as well as methods of use thereof for extra-hepatic islet transplantation.
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124.发明授权公开(公告)号：US09925306B2
公开(公告)日：2018-03-27
申请号：US15401455
申请日：2017-01-09
申请人： BIOALPHA INC.
发明人： Jung Ju Kim , Su Hyun Jung , Hyun Seung Ryu , Jun Hyuk Seo
IPC分类号： A61L27/46 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/20 , C08L5/08 , A61L27/12 , A61L27/58 , C01B25/32 , C08K3/32 , C08K7/18
CPC分类号： A61L27/46 , A61L27/12 , A61L27/20 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/414 , A61L2430/02 , C01B25/327 , C01P2004/32 , C01P2004/61 , C08K3/32 , C08K7/18 , C08K2003/325 , C08K2201/005 , C08L5/08
摘要： The present invention relates to a carrier for growth factor related to regeneration of bone tissues that is capable of arbitrarily controlling the delivery rate of growth factors related to bone regeneration and thus especially applicable to a bone void filler in the fields of the dental or orthopedic applications.The carrier for controlling the delivery rate of the growth factor in the present invention is composed of a hyaluronic acid hydrogel having a distribution of interconnected pores and a calcium phosphate microsphere being distributed in the pores of the hyaluronic acid hydrogel. The calcium phosphate microsphere having a porosity suitable for delivery of the growth factor is positioned into the pores of the cross-linked hyaluronic acid hydrogel to complete the carrier.
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公开(公告)号：US20180078671A1
公开(公告)日：2018-03-22
申请号：US15829440
申请日：2017-12-01
CPC分类号： A61L26/008 , A61L26/0019 , A61L26/0047 , A61L26/0066 , A61L26/0085 , A61L26/009 , A61L27/18 , A61L27/227 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/412 , A61L2400/06 , A61L2430/00 , A61L2430/34 , C08L71/02
摘要： A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.
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公开(公告)号：US20180078379A1
公开(公告)日：2018-03-22
申请号：US15825240
申请日：2017-11-29
IPC分类号： A61F2/44 , A61L27/56 , A61B17/00 , A61L27/52 , A61L27/50 , A61L27/38 , A61L27/18 , A61L27/12 , A61L27/06 , A61K49/00 , A61K9/00 , A61F2/46 , A61F2/28 , A61L27/54 , A61F2/30
CPC分类号： A61F2/441 , A61B17/00234 , A61F2/28 , A61F2/30965 , A61F2/442 , A61F2/4425 , A61F2/4455 , A61F2/446 , A61F2/4465 , A61F2/4601 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30065 , A61F2002/30092 , A61F2002/30131 , A61F2002/302 , A61F2002/30224 , A61F2002/3023 , A61F2002/30308 , A61F2002/30383 , A61F2002/30451 , A61F2002/3055 , A61F2002/30556 , A61F2002/30579 , A61F2002/30583 , A61F2002/30586 , A61F2002/30604 , A61F2002/30622 , A61F2002/30841 , A61F2002/30971 , A61F2002/4475 , A61F2002/448 , A61F2002/4627 , A61F2002/4635 , A61F2002/4677 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2210/0071 , A61F2210/0085 , A61F2220/0016 , A61F2220/0025 , A61F2220/0058 , A61F2230/0013 , A61F2230/0063 , A61F2230/0065 , A61F2230/0069 , A61F2250/0003 , A61F2250/0009 , A61F2250/001 , A61F2250/003 , A61F2250/0065 , A61F2310/00011 , A61F2310/00179 , A61F2310/00365 , A61K9/0024 , A61K49/006 , A61L27/06 , A61L27/12 , A61L27/18 , A61L27/3821 , A61L27/3839 , A61L27/3847 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/256 , A61L2300/404 , A61L2300/414 , A61L2300/43 , A61L2300/64 , A61L2430/02 , A61L2430/38
摘要： An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon.In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.
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127.发明申请公开(公告)号：US20180071430A1
公开(公告)日：2018-03-15
申请号：US15558787
申请日：2016-03-17
发明人： Nadine NASSIF , Francisco Miguel MOREIRA MARTINS FERNANDES , Cedric BOISSIERE , Clement SANCHEZ , Marie-Madeleine GIRAUD-GUILLE
CPC分类号： A61L27/24 , A61K8/022 , A61K8/025 , A61K8/14 , A61K8/606 , A61K8/65 , A61K38/39 , A61K2800/412 , A61K2800/654 , A61K2800/91 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/232 , A61L2300/236 , A61L2300/252 , A61L2300/402 , A61L2300/428 , A61L2400/06 , A61L2430/06 , A61L2430/34 , A61L2430/38 , A61Q19/08 , C08J3/122 , C08J2389/00
摘要： Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.
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公开(公告)号：US20180055649A1
公开(公告)日：2018-03-01
申请号：US15806363
申请日：2017-11-08
IPC分类号： A61F2/44 , A61L27/56 , A61B17/00 , A61L27/52 , A61L27/50 , A61L27/38 , A61L27/18 , A61L27/12 , A61L27/06 , A61K49/00 , A61K9/00 , A61F2/46 , A61F2/28 , A61L27/54 , A61F2/30
CPC分类号： A61F2/441 , A61B17/00234 , A61F2/28 , A61F2/30965 , A61F2/442 , A61F2/4425 , A61F2/4455 , A61F2/446 , A61F2/4465 , A61F2/4601 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30062 , A61F2002/30065 , A61F2002/30092 , A61F2002/30131 , A61F2002/302 , A61F2002/30224 , A61F2002/3023 , A61F2002/30308 , A61F2002/30383 , A61F2002/30451 , A61F2002/3055 , A61F2002/30556 , A61F2002/30579 , A61F2002/30583 , A61F2002/30586 , A61F2002/30604 , A61F2002/30622 , A61F2002/30841 , A61F2002/30971 , A61F2002/4475 , A61F2002/448 , A61F2002/4627 , A61F2002/4635 , A61F2002/4677 , A61F2210/0004 , A61F2210/0014 , A61F2210/0061 , A61F2210/0071 , A61F2210/0085 , A61F2220/0016 , A61F2220/0025 , A61F2220/0058 , A61F2230/0013 , A61F2230/0063 , A61F2230/0065 , A61F2230/0069 , A61F2250/0003 , A61F2250/0009 , A61F2250/001 , A61F2250/003 , A61F2250/0065 , A61F2310/00011 , A61F2310/00179 , A61F2310/00365 , A61K9/0024 , A61K49/006 , A61L27/06 , A61L27/12 , A61L27/18 , A61L27/3821 , A61L27/3839 , A61L27/3847 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/256 , A61L2300/404 , A61L2300/414 , A61L2300/43 , A61L2300/64 , A61L2430/02 , A61L2430/38
摘要： An orthopedic device for implanting between adjacent vertebrae comprising: an arcuate balloon and a hardenable material within said balloon.In some embodiments, the balloon has a footprint that substantially corresponds to a perimeter of a vertebral endplate. An inflatable device is inserted through a cannula into an intervertebral space and oriented so that, upon expansion, a natural angle between vertebrae will be at least partially restored. At least one component selected from the group consisting of a load-bearing component and an osteobiologic component is directed into the inflatable device through a fluid communication means.
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公开(公告)号：US09901660B2
公开(公告)日：2018-02-27
申请号：US14902574
申请日：2014-07-03
发明人： Jacob Klein , Ronit Goldberg , Noa Iuster , Raya Sorkin
CPC分类号： A61L27/52 , A61K9/0019 , A61K9/0024 , A61L27/34 , A61L27/44 , A61L2300/626 , A61L2400/10 , A61L2430/06 , A61L2430/10 , A61L2430/24 , A61L2430/38 , C08F2/10 , C08F2/44 , C09D133/066
摘要： Hydrogels and composite material containing hydrogels and liposomes dispersed therein, which exhibit a reduced friction coefficient compared to neat hydrogels or composites containing hydrogels, processes for preparing the same, and methods for using the same are disclosed.
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公开(公告)号：US20180049744A1
公开(公告)日：2018-02-22
申请号：US15726662
申请日：2017-10-06
申请人： P Tech, LLC
发明人： Peter M. Bonutti
IPC分类号： A61B17/12 , A61L31/04 , A61L27/52 , A61L27/22 , A61K38/48 , A61K35/24 , A61K31/715 , A61K31/215
CPC分类号： A61B17/12 , A61B17/12136 , A61B17/1325 , A61B17/135 , A61B17/70 , A61B17/72 , A61B17/8847 , A61B18/14 , A61B2017/005 , A61B2017/00893 , A61B2017/12004 , A61B2018/00011 , A61B2018/00023 , A61B2018/0022 , A61F2/38 , A61F2/44 , A61K31/215 , A61K31/715 , A61K35/24 , A61K38/4833 , A61L27/222 , A61L27/52 , A61L31/045 , A61L31/145 , A61L2400/04
摘要： The present disclosure provides a method of positioning a medical device in a patient. The method includes coating a balloon with a substance, wherein the coating substance comprises at least one layer comprised at least partially of a medicinal agent and a polymer, inserting the deflated balloon into a cardiac system of the patient, placing the balloon in the proper location in the cardiac system of the patient, and inflating the balloon by injecting a sterile liquid from a syringe into the balloon. The method also includes positioning the substance proximate the tissue of the cardiac system of the patient, wherein the cardiovascular drug medicinal agent comprising the substance is drug eluting.
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