公开(公告)号：US20050079603A1

公开(公告)日：2005-04-14

申请号：US10968556

申请日：2004-10-19

申请人： Perry Sandstrom

发明人： Perry Sandstrom

IPC分类号： G01N21/64 ,  C12Q1/68 ,  C12M1/34 ,  C12M3/00

CPC分类号： G01N21/6452 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00439 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00639 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00693 ,  B01J2219/00704 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B60/08 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6456

摘要： The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention provides micromirror systems for synthesizing and acquiring data from nucleic acid microarrays and systems for collecting, processing, and analyzing data obtained from a microarray.

摘要翻译： 本发明涉及包含用于微阵列读取和合成的空间光调制器的新型系统，装置和方法。 例如，本发明提供用于从核酸微阵列合成和获取数据的微镜系统以及用于收集，处理和分析从微阵列获得的数据的系统。

公开(公告)号：US20050019794A1

公开(公告)日：2005-01-27

申请号：US10827917

申请日：2004-04-19

申请人： Hany Nassef ,  Geoffrey Facer ,  Joseph Barco

发明人： Hany Nassef ,  Geoffrey Facer ,  Joseph Barco

IPC分类号： A01N43/62 ,  A61K31/55 ,  B01D20060101 ,  C12Q1/68 ,  C30B7/00 ,  C30B7/08 ,  C30B7/10 ,  C30B7/14 ,  C30B29/58 ,  C30B35/00

CPC分类号： C30B29/54 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00355 ,  B01J2219/00389 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00756 ,  C30B7/00 ,  C30B29/58 ,  C30B35/002 ,  C40B40/06 ,  C40B40/10 ,  C40B60/08

摘要： High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated fluidic device. The microfabricated fluidic device is then manipulated to vary the solution condition in the chambers, thereby simultaneously providing a large number of crystallization environments. Control over changed solution conditions may result from a variety of techniques, including but not limited to metering volumes of crystallizing agent into the chamber by volume exclusion, by entrapment of volumes of crystallizing agent determined by the dimensions of the microfabricated structure, or by cross-channel injection of sample and crystallizing agent into an array of junctions defined by intersecting orthogonal flow channels.

摘要翻译： 目标材料的结晶化的高通量筛选是通过将目标材料的溶液同时引入微细加工的流体装置的多个室来实现的。 然后对微制造的流体装置进行操作以改变室中的溶液状态，从而同时提供大量的结晶环境。 改变的溶液条件的控制可以由各种技术产生，包括但不限于通过体积排阻将结晶剂计量到室中的体积，通过捕获通过微结构结构的尺寸确定的结晶剂的体积， 将样品和结晶剂通道注入由相交的正交流动通道限定的连接阵列。

公开(公告)号：US06794052B2

公开(公告)日：2004-09-21

申请号：US10226485

申请日：2002-08-22

申请人： Peter G. Schultz ,  Xiao-Dong Xiang ,  Isy Goldwasser ,  Gabriel Briceño ,  Xiao-Dong Sun

发明人： Peter G. Schultz ,  Xiao-Dong Xiang ,  Isy Goldwasser ,  Gabriel Briceño ,  Xiao-Dong Sun

IPC分类号： B32B2700

CPC分类号： C04B35/16 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00432 ,  B01J2219/00436 ,  B01J2219/00441 ,  B01J2219/00443 ,  B01J2219/00475 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00531 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00646 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00736 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00752 ,  B01J2219/00754 ,  B82Y25/00 ,  B82Y30/00 ,  C01G51/006 ,  C01G51/68 ,  C01P2002/34 ,  C01P2002/52 ,  C01P2002/72 ,  C01P2006/40 ,  C01P2006/42 ,  C04B35/01 ,  C04B35/4508 ,  C04B35/4521 ,  C04B35/4525 ,  C04B35/62218 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3224 ,  C04B2235/3225 ,  C04B2235/3227 ,  C04B2235/3262 ,  C04B2235/327 ,  C04B2235/3275 ,  C04B2235/3284 ,  C04B2235/3286 ,  C04B2235/3296 ,  C04B2235/3298 ,  C04B2235/3418 ,  C04B2235/3463 ,  C04B2235/656 ,  C04B2235/761 ,  C04B2235/762 ,  C04B2235/768 ,  C04B2235/96 ,  C23C14/042 ,  C23C14/087 ,  C23C16/042 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B60/08 ,  C40B60/14 ,  C40B70/00 ,  C40B80/00 ,  G01R33/16 ,  H01F1/401 ,  H01F1/407 ,  H01F10/007 ,  H01F10/1933 ,  H01F41/18 ,  H01F41/34 ,  H01L43/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  Y10T428/2462 ,  Y10T428/31 ,  Y10T428/31645 ,  Y10T428/31855 ,  Y10T428/31931 ,  Y10T436/25 ,  Y10T436/2525 ,  Y10T436/255 ,  Y10T436/25875

摘要： Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.

摘要翻译： 用于制备和使用在其上的预定区域中具有不同材料阵列的基材的方法和装置。 通常通过将材料的组分递送到衬底上的预定区域，并且同时使组分反应以形成至少两种材料来制备其上具有不同材料阵列的衬底。 可以使用本发明的方法和装置制备的材料包括例如共价网络固体，离子固体和分子固体。 更具体地，可以使用本发明的方法和装置制备的材料包括例如无机材料，金属间材料，金属合金，陶瓷材料，有机材料，有机金属材料，非生物有机聚合物，复合材料（例如 ，无机复合材料，有机复合材料或其组合）等。一旦制备，可以对这些材料进行筛选以获得有用的性质，包括例如电，热，机械，形态，光学，磁性，化学或其它性质。 因此，本发明提供了用于并行合成和分析具有有用特性的新型材料的方法。

公开(公告)号：US20040029303A1

公开(公告)日：2004-02-12

申请号：US10214951

申请日：2002-08-07

发明人： Mark Whitney Hart ,  Ho-Cheol Kim ,  Robert Dennis Miller ,  Gregory Michael Wallraff

IPC分类号： H01L021/00

CPC分类号： B01L3/5085 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00644 ,  B01L2200/12 ,  B01L2300/0609 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/165 ,  B01L2300/168 ,  C40B60/08

摘要： A biomolecular array includes a substrate across which is distributed an array of discrete regions of a porous substance. The porous substance is designed to bind chemical targets useful in biotechnology applications, such as gene expression, protein, antibody, and antigen experiments. The regions are preferably optically isolated from each other and may be shaped to enhance detection of optical radiation emanating from the porous substance, e.g., as a result of irradiation of the regions with ultraviolet light. The discrete regions may be configured as microscopic wells within the substrate, or they may reside on top of the substrate in the form of microscopic mesas.

摘要翻译： 生物分子阵列包括分布有多孔物质的离散区域的阵列的基底。 多孔物质被设计用于结合可用于生物技术应用的化学靶，例如基因表达，蛋白质，抗体和抗原实验。 这些区域优选地彼此光学隔离，并且可以被成形为增强从多孔物质发出的光辐射的检测，例如，作为由紫外线照射该区域的结果。 离散区域可以被配置为衬底内的微观阱，或者它们可以以微观台面的形式驻留在衬底的顶部上。

公开(公告)号：US20030174324A1

公开(公告)日：2003-09-18

申请号：US10408870

申请日：2003-04-08

发明人： Perry Sandstrom

IPC分类号： G01N021/64

CPC分类号： G01N21/6452 ,  B01J2219/00378 ,  B01J2219/00387 ,  B01J2219/00439 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00639 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00693 ,  B01J2219/00704 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B60/08 ,  G01J3/02 ,  G01J3/021 ,  G01J3/0229 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6456

摘要： The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention provides micromirror systems for synthesizing and acquiring data from nucleic acid microarrays and systems for collecting, processing, and analyzing data obtained from a microarray.

公开(公告)号：US06346290B1

公开(公告)日：2002-02-12

申请号：US09127195

申请日：1998-07-31

申请人： Peter G. Schultz ,  Xiaodong Xiang ,  Isy Goldwasser

发明人： Peter G. Schultz ,  Xiaodong Xiang ,  Isy Goldwasser

IPC分类号： B05D106

CPC分类号： C04B35/16 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00432 ,  B01J2219/00436 ,  B01J2219/00441 ,  B01J2219/00443 ,  B01J2219/00475 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00531 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00646 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00736 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00752 ,  B01J2219/00754 ,  B82Y25/00 ,  B82Y30/00 ,  C01G51/006 ,  C01G51/68 ,  C01P2002/34 ,  C01P2002/52 ,  C01P2002/72 ,  C01P2006/40 ,  C01P2006/42 ,  C04B35/01 ,  C04B35/4508 ,  C04B35/4521 ,  C04B35/4525 ,  C04B35/62218 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3224 ,  C04B2235/3225 ,  C04B2235/3227 ,  C04B2235/3262 ,  C04B2235/327 ,  C04B2235/3275 ,  C04B2235/3284 ,  C04B2235/3286 ,  C04B2235/3296 ,  C04B2235/3298 ,  C04B2235/3418 ,  C04B2235/3463 ,  C04B2235/656 ,  C04B2235/761 ,  C04B2235/762 ,  C04B2235/768 ,  C04B2235/96 ,  C23C14/042 ,  C23C14/087 ,  C23C16/042 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B60/08 ,  C40B60/14 ,  C40B70/00 ,  C40B80/00 ,  G01R33/16 ,  H01F1/401 ,  H01F1/407 ,  H01F10/007 ,  H01F10/1933 ,  H01F41/18 ,  H01F41/34 ,  H01L43/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  Y10T428/2462 ,  Y10T428/31 ,  Y10T428/31645 ,  Y10T428/31855 ,  Y10T428/31931 ,  Y10T436/25 ,  Y10T436/2525 ,  Y10T436/255 ,  Y10T436/25875

摘要： Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.

公开(公告)号：US5985356A

公开(公告)日：1999-11-16

申请号：US327513

申请日：1994-10-18

申请人： Peter G. Schultz ,  Xiaodong Xiang ,  Isy Goldwasser

发明人： Peter G. Schultz ,  Xiaodong Xiang ,  Isy Goldwasser

IPC分类号： C01G1/00 ,  B01J19/00 ,  C01G51/00 ,  C04B35/01 ,  C04B35/45 ,  C04B35/622 ,  C07B61/00 ,  C23C14/04 ,  C23C14/08 ,  C23C16/04 ,  C40B30/08 ,  C40B40/14 ,  C40B40/18 ,  C40B60/14 ,  C40B70/00 ,  G01N27/00 ,  G01N35/02 ,  G01N37/00 ,  G01R33/16 ,  H01F1/40 ,  H01F10/00 ,  H01F10/18 ,  H01F10/193 ,  H01F41/18 ,  H01F41/34 ,  H01L43/10 ,  H01L43/12 ,  B05D1/34 ,  B05D1/36 ,  G01N1/28 ,  G01N21/00

CPC分类号： C04B35/16 ,  B01J19/0046 ,  B82Y30/00 ,  C01G51/006 ,  C01G51/68 ,  C04B35/01 ,  C04B35/4508 ,  C04B35/4521 ,  C04B35/4525 ,  C04B35/62218 ,  C23C14/042 ,  C23C14/087 ,  C23C16/042 ,  C40B40/14 ,  C40B40/18 ,  C40B60/08 ,  C40B80/00 ,  G01R33/16 ,  H01F1/407 ,  H01F10/007 ,  H01F10/1933 ,  H01F41/18 ,  H01F41/34 ,  H01L43/10 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00378 ,  B01J2219/0043 ,  B01J2219/00432 ,  B01J2219/00436 ,  B01J2219/00441 ,  B01J2219/00443 ,  B01J2219/00475 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00515 ,  B01J2219/0052 ,  B01J2219/00527 ,  B01J2219/00531 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/0054 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/0063 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00646 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00736 ,  B01J2219/00745 ,  B01J2219/00747 ,  B01J2219/00752 ,  B01J2219/00754 ,  B82Y25/00 ,  C01P2002/34 ,  C01P2002/52 ,  C01P2002/72 ,  C01P2006/40 ,  C01P2006/42 ,  C04B2235/3206 ,  C04B2235/3208 ,  C04B2235/3213 ,  C04B2235/3215 ,  C04B2235/3224 ,  C04B2235/3225 ,  C04B2235/3227 ,  C04B2235/3262 ,  C04B2235/327 ,  C04B2235/3275 ,  C04B2235/3284 ,  C04B2235/3286 ,  C04B2235/3296 ,  C04B2235/3298 ,  C04B2235/3418 ,  C04B2235/3463 ,  C04B2235/656 ,  C04B2235/761 ,  C04B2235/762 ,  C04B2235/768 ,  C04B2235/96 ,  C40B30/08 ,  C40B60/14 ,  C40B70/00 ,  H01F1/401 ,  Y10T428/24479 ,  Y10T428/24612 ,  Y10T428/2462 ,  Y10T428/31 ,  Y10T428/31645 ,  Y10T428/31855 ,  Y10T428/31931 ,  Y10T436/25 ,  Y10T436/2525 ,  Y10T436/255 ,  Y10T436/25875

摘要： Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties.

公开(公告)号：US20180080020A1

公开(公告)日：2018-03-22

申请号：US15694108

申请日：2017-09-01

申请人： Raindance Technologies, Inc.

发明人： Darren Roy Link ,  Laurent Boitard ,  Jeffrey Branciforte ,  Yves Charles ,  Gilbert Feke ,  John Q. Lu ,  David Marran ,  Ahmadali Tabatabai ,  Michael Weiner ,  Wolfgang Hinz ,  Jonathan M. Rothberg

IPC分类号： C12N15/10 ,  G01N33/68 ,  B01F13/00 ,  G01N33/543 ,  G01N33/536 ,  C40B70/00 ,  C40B60/12 ,  C40B60/08 ,  C40B50/08 ,  C40B40/04 ,  C40B30/04 ,  C12Q1/68 ,  C07K1/04 ,  B82Y30/00 ,  B82Y5/00 ,  B01L3/00 ,  B01J19/00 ,  G01N33/542 ,  G01N21/64 ,  B01L7/00 ,  B01F3/08

CPC分类号： B01F3/0807 ,  B01F13/0071 ,  B01F13/0076 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/00479 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00599 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00743 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502784 ,  B01L3/502792 ,  B01L3/565 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/0621 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0896 ,  B01L2400/0415 ,  B01L2400/0424 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y5/00 ,  B82Y30/00 ,  C07K1/047 ,  C12N15/1075 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6834 ,  C12Q1/686 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q2525/161 ,  C12Q2561/119 ,  C12Q2563/103 ,  C12Q2563/107 ,  C12Q2563/159 ,  C12Q2565/537 ,  C12Q2565/629 ,  C12Q2600/16 ,  C40B30/04 ,  C40B40/04 ,  C40B50/08 ,  C40B60/08 ,  C40B60/12 ,  C40B70/00 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/6458 ,  G01N33/536 ,  G01N33/542 ,  G01N33/543 ,  G01N33/6845 ,  G01N33/6854 ,  G01N2500/10

摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.

公开(公告)号：US20170354946A1

公开(公告)日：2017-12-14

申请号：US15669080

申请日：2017-08-04

申请人： The University Court of the University of Glasgow

发明人： Leroy CRONIN

IPC分类号： B01J19/00 ,  C40B50/04 ,  C40B60/08

CPC分类号： B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/007 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00738 ,  B01J2219/00747 ,  B01J2219/00756 ,  C40B50/04 ,  C40B60/08

摘要： The invention provides a method for preparing a compound or a product having one or more characteristics that meet or exceed a user specification, the process comprising the step of selecting a first combination of chemical inputs, optionally together with physical inputs, and supplying those inputs to a reaction space, thereby to generate a first product; analysing one or more characteristics of the product generated; comparing the one or more characteristics against a user specification; using a genetic algorithm selecting a second combination of chemical inputs, optionally together with physical inputs, wherein the second combination differs from the first combination, and supplying those inputs to the reaction space, thereby to generate a second product; analysing one or more characteristics of the second product generated; comparing the one or more characteristics generated against the user specification; repeating the selecting and analysing steps for further individual combinations of chemical and/or physical inputs, to provide an array of products wherein the flow chemistry system operates continuously to provide the first, second and further products, thereby to identify one or more products meeting or exceeding the user specification.

公开(公告)号：US09534216B2

公开(公告)日：2017-01-03

申请号：US14248991

申请日：2014-04-09

申请人： Raindance Technologies, Inc.

发明人： Darren R. Link ,  Laurent Boitard ,  Jeffrey Branciforte ,  Yves Charles ,  Gilbert Feke ,  John Q. Lu ,  David Marran ,  Ahmadali Tabatabai ,  Michael Weiner ,  Wolfgang Hinz ,  Jonathan M. Rothberg

IPC分类号： G01N15/10 ,  C12Q1/68 ,  G01N21/00 ,  G01N21/21 ,  C12N15/10 ,  B01F13/00 ,  B01J19/00 ,  B82Y5/00 ,  B82Y30/00 ,  C07K1/04 ,  C40B30/04 ,  C40B40/04 ,  C40B50/08 ,  C40B60/08 ,  C40B60/12 ,  C40B70/00 ,  G01N33/536 ,  G01N33/68 ,  G01N33/543 ,  G01N33/50 ,  G01N33/00 ,  B01L3/00 ,  B01F3/08 ,  G01N33/542 ,  G01N21/64 ,  B01L7/00

CPC分类号： C12N15/1075 ,  B01F3/0807 ,  B01F13/0071 ,  B01F13/0076 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/00468 ,  B01J2219/00479 ,  B01J2219/005 ,  B01J2219/00576 ,  B01J2219/00599 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00743 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502784 ,  B01L3/502792 ,  B01L3/565 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/0621 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0896 ,  B01L2400/0415 ,  B01L2400/0424 ,  B01L2400/0487 ,  B01L2400/084 ,  B82Y5/00 ,  B82Y30/00 ,  C07K1/047 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6834 ,  C12Q1/686 ,  C12Q1/6869 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q2525/161 ,  C12Q2561/119 ,  C12Q2563/103 ,  C12Q2563/107 ,  C12Q2563/159 ,  C12Q2565/537 ,  C12Q2565/629 ,  C12Q2600/16 ,  C40B30/04 ,  C40B40/04 ,  C40B50/08 ,  C40B60/08 ,  C40B60/12 ,  C40B70/00 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/6458 ,  G01N33/536 ,  G01N33/542 ,  G01N33/543 ,  G01N33/6845 ,  G01N33/6854 ,  G01N2500/10

摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library.

摘要翻译： 本发明提供了可用于进行高通量筛选测定和组合化学的新型微流体装置和方法。 本发明提供了含有唯一标记的细胞，酶，核酸等的含水基乳液，其中乳液还包含引物，标记，探针和其它反应物。 油基载体流体在微流体装置上包封乳剂库，使得连续通道提供不混溶流体的流动，以实现乳液库的汇集，聚结，混合，分选，检测等。