公开(公告)号：US20240198338A1

公开(公告)日：2024-06-20

申请号：US18595920

申请日：2024-03-05

Applicant: The General Hospital Corporation

Inventor： Ravi Kapur ,  Kyle C. Smith ,  Mehmet Toner

IPC: B01L3/00 ,  A61K35/28 ,  G01N1/40 ,  G01N15/00 ,  G01N15/01 ,  G01N15/02 ,  G01N15/06 ,  G01N15/14 ,  G01N15/149

CPC classification number: B01L3/502761 ,  A61K35/28 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502753 ,  G01N1/4077 ,  G01N15/0255 ,  G01N15/0618 ,  G01N15/1484 ,  B01L3/502776 ,  B01L2200/0631 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0877 ,  B01L2300/185 ,  B01L2400/0409 ,  B01L2400/0415 ,  B01L2400/043 ,  B01L2400/0436 ,  B01L2400/0457 ,  B01L2400/0487 ,  B01L2400/082 ,  G01N2001/4088 ,  G01N2015/0053 ,  G01N15/01 ,  G01N2015/0288 ,  G01N2015/1486 ,  G01N15/149 ,  G01N2015/1493

Abstract: A microfluidic device includes a particle sorting region having a first, second and third microfluidic channels, a first array of islands separating the first microfluidic channel from the second microfluidic channel, and a second array of islands separating the first microfluidic channel from the third microfluidic channel, in which the island arrays and the microfluidic channels are arranged so that a first fluid is extracted from the first microfluidic channel into the second microfluidic channel and a second fluid is extracted from the third microfluidic channel into the first microfluidic channel, and so that particles are transferred from the first fluid sample into the second fluid sample within the first microfluidic channel.

公开(公告)号：US12000768B2

公开(公告)日：2024-06-04

申请号：US17247096

申请日：2020-11-30

Applicant: Honeywell International Inc.

Inventor： Andy Walker Brown ,  Adam D. McBrady ,  Ryadh Abdullah Zakaria ,  Stephan Michael Bork

IPC: G01N15/02 ,  G01N1/22 ,  G01N15/0227 ,  G06T7/62 ,  G06V10/75 ,  G01N15/01

CPC classification number: G01N1/2273 ,  G01N15/0227 ,  G06T7/62 ,  G06V10/751 ,  G01N15/01 ,  G01N2015/0233

Abstract: A flow device, method, and system are provided for determining the fluid particle composition. An example flow device includes a fluid sensor configured to monitor at least one particle characteristic of fluid flowing through the fluid sensor. The example flow device also includes at least one processor configured to, upon determining the at least one particle characteristic satisfies a particle criteria, generate a control signal for an external device. The example flow device also includes a fluid composition sensor configured to be powered based on the control signal and further configured to capture data relating to the fluid particle composition. The example flow device is also configured to generate one or more particle profiles of at least one component of the fluid based on the data captured by the fluid composition sensor.

公开(公告)号：US11977017B2

公开(公告)日：2024-05-07

申请号：US16254958

申请日：2019-01-23

Applicant: International Business Machines Corporation

Inventor： Marta Sanchez-Martin ,  Claudia S. Huettner ,  Jia Xu ,  Cheryl L Eifert ,  Elinor Dehan ,  Shang Xue ,  Vanessa Michelini

IPC: G01N15/10 ,  G01N15/01 ,  G01N15/14 ,  G01N15/149 ,  G06F30/27 ,  G16B40/00 ,  G16B40/20 ,  G16C20/70 ,  H04L67/01

CPC classification number: G01N15/1012 ,  G06F30/27 ,  G16B40/00 ,  G16B40/20 ,  G16C20/70 ,  G01N15/01 ,  G01N2015/1006 ,  G01N15/1459 ,  G01N15/149 ,  H04L67/01

Abstract: Computer based methods, systems, and computer readable media are provided for intelligently sorting cells using machine learning. A biological cell analysis sorting machine, wherein the biological cell analysis sorting machine comprises a flow cytometry system and a cell analytics sorting system, may be configured to detect configuration issues by analyzing results of a sorting experiment performed by the biological cell analysis sorting machine. An analysis of a history of prior sorting experiments and associated configuration settings may be performed and a corpus of documents pertaining to the sorting experiment based on the detected configuration issues may be analyzed. Updated configuration settings for the biological cell analysis sorting machine based on the performed analysis may be determined, and the biological cell analysis sorting machine may be configured with the updated configuration settings to conduct a desired sorting experiment.

公开(公告)号：US20240142363A1

公开(公告)日：2024-05-02

申请号：US18278864

申请日：2022-01-18

Applicant: Yokogawa Electric Corporation

Inventor： Tomoyuki TAGUCHI ,  Yuki MIYAUCHI ,  Hiroyuki KATAYAMA

IPC: G01N15/075 ,  C12Q1/6813 ,  G01N15/01

CPC classification number: G01N15/075 ,  C12Q1/6813 ,  G01N15/01 ,  C12Q1/686

Abstract: A measurement method for quantitatively measuring amounts of at least two varieties of microorganisms in a test sample. The measurement method includes: producing a first sample by performing step dilution and division of the test sample; producing a second sample by amplifying nucleic acids of the microorganisms in the first sample; and performing hybridization of the second sample in a probe array including spots to which probes having complementary sequences to target nucleic acids specific to each of the varieties of the microorganisms are fixed; and identifying the varieties of the microorganisms based on light emission from the spots where the hybridization is performed and quantitatively measuring amounts of the microorganisms by a most probable number method.

公开(公告)号：US12130220B2

公开(公告)日：2024-10-29

申请号：US17634637

申请日：2020-03-19

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chil Min Kim ,  Jin Hyeok Ryu ,  Chang Hwan Yi

IPC: G01N15/06 ,  G01N15/01 ,  G01N15/075

CPC classification number: G01N15/0606 ,  G01N15/01 ,  G01N15/075

Abstract: A biosensor using an exceptional point is disclosed. A biosensor according to one embodiment of the present disclosure includes: a biosensing unit configured to output wavelength-separated optical signals from destruction of an exceptional point resulting from attachment of biomolecules; a detection unit configured to convert the wavelength-separated optical signals into wavelength-separated electrical signals; an analysis unit configured to measure a beat frequency resulting from the wavelength-separated electrical signals; and a determination unit configured to determine a wavelength difference resulting from the beat frequency, thereby determining the amount of the biomolecules therefrom.

公开(公告)号：US12114973B2

公开(公告)日：2024-10-15

申请号：US17579525

申请日：2022-01-19

Applicant: Fresenius Medical Care Holdings, Inc.

Inventor： Louis LeeGrande Barrett

IPC: A61B5/1455 ,  G01J1/02 ,  G01J3/02 ,  G01J3/28 ,  G01J3/42 ,  G01N15/06 ,  G01N21/27 ,  G01N21/31 ,  G01N21/3577 ,  G01N33/49 ,  A61B5/00 ,  G01J1/44 ,  G01N15/01 ,  G01N15/075

CPC classification number: A61B5/1455 ,  A61B5/14557 ,  G01J1/0214 ,  G01J3/0205 ,  G01J3/28 ,  G01J3/42 ,  G01N15/06 ,  G01N21/274 ,  G01N21/314 ,  G01N21/3577 ,  G01N33/49 ,  A61B5/0022 ,  A61B2560/0223 ,  G01J2001/444 ,  G01N15/01 ,  G01N15/075 ,  G01N2201/062 ,  G01N2201/0624

Abstract: A measurement system for measuring blood characteristics includes a controller, an emitter, a sensor, and a reference sensor. The emitter emits light at a plurality of wavelengths from a first side of a blood flow channel to a second side of the blood flow channel. The sensor is provided on the second side of the blood flow channel. The reference sensor is provided on the first side of the blood flow channel. The controller compensates measurements from the sensor based upon measurements from the reference sensor. The reference sensor may be disposed in a position to increase noise immunity of the measurement system. The measurement system may be connected to or part of a dialysis system.

公开(公告)号：US12085528B2

公开(公告)日：2024-09-10

申请号：US16311619

申请日：2015-05-14

Applicant: INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Ki-Ho Han ,  Jin-Ho Kim

IPC: G01N27/30 ,  B01L3/00 ,  B01L3/02 ,  C12M1/00 ,  C12M1/34 ,  C12M1/42 ,  G01N15/01 ,  G01N15/10 ,  G01N15/14

CPC classification number: G01N27/30 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502753 ,  B01L3/502761 ,  C12M1/34 ,  C12M1/42 ,  C12M47/04 ,  G01N15/10 ,  B01L3/0241 ,  B01L2200/0642 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2400/0487 ,  G01N15/01 ,  G01N2015/1024 ,  G01N2015/1029 ,  G01N15/1459

Abstract: An apparatus and method for separating single cells. The apparatus includes: a fluid channel having an upper panel, a lower panel, and a flow path formed therebetween that is configured to convey a sample including a single cell; a single cell measuring unit including first and second electrodes provided on the fluid channel in a predetermined spaced relationship for applying electrical signals to the sample in the flow path, and a detection electrode provided between the first and second electrodes to detect the single cell in the sample in the flow path, such that the single cell measuring unit applies the electrical signals to the sample in the flow path, detects the electrical signals of the sample, and detects whether there is the single cell in the sample; and a single cell separation control device which outputs a single cell separation control signal when the single cell is detected by the detection electrode.

公开(公告)号：US12082938B2

公开(公告)日：2024-09-10

申请号：US17533278

申请日：2021-11-23

Applicant: Barbara Smith ,  Christopher Miranda

Inventor： Barbara Smith ,  Christopher Miranda

IPC: A61B5/00 ,  G01N15/10 ,  G01N15/01

CPC classification number: A61B5/4064 ,  A61B5/0095 ,  G01N15/1023 ,  G01N15/01 ,  G01N2015/1006

Abstract: A system for measuring a membrane potential is disclosed. The system comprises a photoacoustic probe including a laser and an ultrasound transducer. The laser is configured to emit a light signal at one or more wavelengths to a neuronal cell. The neuronal cell may comprise a voltage-sensitive protein configured to absorb the light signal in a voltage-dependent manner. The ultrasound transducer is configured to receive a photoacoustic signal from the voltage-sensitive protein in response to absorbing the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer and calculate a membrane potential of the neuron based on the photoacoustic signal. Methods of measuring a membrane potential and biomaterials related to the voltage-sensitive protein are also disclosed herein.

公开(公告)号：US20240296902A1

公开(公告)日：2024-09-05

申请号：US18598979

申请日：2024-03-07

Applicant: Liposcience, Inc.

Inventor： James D. Otvos

IPC: G16B5/00 ,  G01N15/01 ,  G01N15/06 ,  G01N24/08 ,  G01N33/483 ,  G01R33/465 ,  G16B40/00 ,  G16H10/40 ,  G16H20/00 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50

CPC classification number: G16B5/00 ,  G01N15/0656 ,  G01N24/08 ,  G01N33/4833 ,  G01R33/465 ,  G16B40/00 ,  G16H10/40 ,  G16H20/00 ,  G16H50/20 ,  G16H50/30 ,  G16H50/50 ,  G01N15/01 ,  G01N2800/323 ,  G01N2800/324

Abstract: Methods, computer program products and apparatus determine a subject's risk of having or developing CHD using a calculated HDL particle risk number and/or a mathematical model of risk associated with HDL particles that adjusts concentrations of at least one of the subclasses of small, medium and large HDL particle measurements to reflect predicted CHD risk. A calculated LDL particle risk number may also be generated as well as a lipoprotein particle index derived from the ratio of RLDL/RHDL.

公开(公告)号：US20240295487A1

公开(公告)日：2024-09-05

申请号：US18270795

申请日：2022-01-25

Applicant: NANOENTEK, INC.

Inventor： Chan Il CHUNG ,  Hyoung Seop LEE ,  Sanghwa AHN

IPC: G01N15/1433 ,  G01N15/01 ,  G01N15/14

CPC classification number: G01N15/1433 ,  G01N15/1456 ,  G01N15/01 ,  G01N2015/1486

Abstract: In a fine particle counting method using a multi-channel sample chip and a fine particle counting apparatus implementing the method, a plurality of samples is observable in a short period of time and even when warpage occurs during a manufacturing process as a sample chip becomes larger, the warpage is corrected so as to count fine particles accurately. Problems that a focal distance of each channel is not constant due to warpage occurring in a chip having a plurality of channels, and thus it takes a lot of time to obtain an image by obtaining a focus value for each channel may be solved. A problem that since an amount of sample injected into each channel is small, a sample dries out when an image is not quickly obtained and used for counting, thereby causing the occurrence of measurement error may be prevented.