-
公开(公告)号：US20180187248A1
公开(公告)日：2018-07-05
申请号：US15720159
申请日：2017-09-29
发明人： Fengchun PANG , Peizhi CAI , Yue GENG
CPC分类号： C12Q1/6837 , B01L3/5027 , B01L3/502761 , B01L2200/0647 , B01L2300/0645 , B01L2300/0816 , B01L2300/0887 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , C12Q2565/513 , G01N31/22 , G01N33/48721 , C12Q2563/116 , C12Q2563/159 , C12Q2565/607
摘要： The present disclosure provides a gene sequencing chip, a gene sequencing apparatus and a gene sequencing method. The gene sequencing chip comprising: a transparent first substrate; a second substrate disposed opposite to the first substrate; a first electrode disposed on the first substrate, which is a transparent electrode; an electronic ink layer disposed between the first substrate and the second substrate; and a microporous layer disposed on a side of the second substrate away from the first substrate. Micropores is formed at a position in the microporous layer corresponding to the first electrode.
-
公开(公告)号：US09995684B2
公开(公告)日：2018-06-12
申请号：US14533314
申请日：2014-11-05
发明人： Susanne Seidel , Dieter Braun , Stefan Duhr , Philipp Baaske
CPC分类号： G01N21/6486 , B01L3/0268 , B01L3/5027 , B01L3/50851 , B01L2200/0642 , B01L2200/0673 , B01L2300/0663 , B01L2300/0819 , B01L2300/0829 , B01L2300/0838 , B01L2300/1872 , B01L2400/0451 , G01N15/0205 , G01N21/645 , G01N21/6456 , G01N2201/06113
摘要： The present invention relates generally to a system and a method for thermo-optical measurements in a droplet of aqueous solution comprising particles of interest, the method comprising the following steps: providing the droplet of aqueous solution with a volume of less than 200 nl, wherein the aqueous solution is a first liquid and at least a part of the particles of interest are fluorescent particles; embedding the droplet of aqueous solution at least partly in a second liquid; irradiating a laser light beam into the droplet to obtain a spatial temperature distribution in the droplet around the irradiated laser light beam; exciting fluorescently said fluorescent particles and detecting fluorescence at least at one position or at around one position in the droplet or detecting the fluorescence distribution of said fluorescently excited particles, wherein said detection of fluorescence is performed at least once at a predetermined time after the start of the laser irradiation; and determining a characteristic of the particles of interest from the detected fluorescence intensity or fluorescence intensity distribution.
-
公开(公告)号：US09994891B2
公开(公告)日：2018-06-12
申请号：US14350095
申请日：2012-10-11
申请人： QIAGEN GMBH
发明人： Andy Wende , Rainer Dahlke , Ralf Himmelreich , Thomas Rothmann , Michael Eberhard , Gerd Grosshauser , Markus Jeziorski , Hans Attig , Josef Drexler , Eva Holzer
CPC分类号： C12Q1/689 , B01L3/5027 , B01L3/5082 , B01L7/52 , B01L2200/025 , B01L2200/026 , B01L2200/0689 , B01L2200/16 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2400/0487 , C12Q1/6806 , C12Q1/686 , C12Q1/6888
摘要： The present invention pertains inter alia to a method for analyzing a sample comprising biomolecules, which comprises the following steps: A a) lysing the sample to provide a lysed sample and optionally clearing the lysed sample; b) contacting at least a portion of the lysed sample with a dry composition comprising reagents for performing the analytical method, thereby providing a reconstituted composition; c) performing an analytical method using the reconstituted composition; or B a) contacting the sample with a lysis solution thereby providing a lysis mixture; b) using the lysis mixture to reconstitute a dry composition comprising reagents for performing the analytical method, thereby providing a reconstituted composition; c) performing an analytical method using the reconstituted composition, wherein the reconstituted composition is optionally cleared and wherein subsequent to step b) at least one step is performed which supports the lysis of the sample. Furthermore, specifically adapted processing cartridges and systems are provided.
-
公开(公告)号：US09994805B2
公开(公告)日：2018-06-12
申请号：US14404225
申请日：2013-05-31
发明人： Nancy Allbritton , Yuli Wang , Christopher Sims
CPC分类号： C12M23/16 , B01L3/5027 , B01L3/502707 , B01L2200/0684 , B01L2200/12 , B01L2300/161 , B81B2201/058 , B81C1/00206 , C12M23/12 , C12M29/20 , C12Q1/02 , G01N2035/00158
摘要： A microfabricated device having at least one gas-entrapping feature formed therein in a configuration that entraps air bubbles upon wetting the feature with a solvent or solution is described. The device includes a sacrificial residue in contact with the gas-entrapping feature, the dissolution of which guides the wetting of the gas-entrapping feature.
-
公开(公告)号：US20180156795A1
公开(公告)日：2018-06-07
申请号：US15884347
申请日：2018-01-30
IPC分类号： G01N33/569 , G01N21/17
CPC分类号： G01N33/56911 , B01L3/5027 , B01L3/502715 , B01L3/5085 , B01L2200/0605 , B01L2200/0684 , B01L2300/021 , B01L2300/0816 , B01L2300/0829 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/16 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B01L2400/0688 , B01L2400/0694 , G01N21/17 , G01N33/579 , G01N2400/10 , G01N2400/50 , Y10T436/2575
摘要： Methods and systems for measuring the concentration of LAL-reactive substances in fluid samples is provided. They include contacting an aqueous sample with a detection reagent to form a prepared sample. A physical property of the prepared sample may be measured to obtain at least one sample measurement characteristic of the prepared sample. Curve fitting may then be used to forecast a concentration of the LAL-reactive substance the aqueous sample will have at a specified time in the future based on the sample measurement and a correlation developed between at least one standard measurement of a physical quality of a solution with a known concentration of a LAL-reactive substance therein. The quality of the sample measurement may be validated using historical data and/or the standard measurement.
-
公开(公告)号：US09989523B2
公开(公告)日：2018-06-05
申请号：US14942921
申请日：2015-11-16
申请人： LEUKODX LTD.
发明人： Harvey Lee Kasdan , Julien Meissonnier , Yoav Zuta , Bruce Davis , Micha Rosen , Yael Himmel , Yehoshua Broder
IPC分类号： G01N33/53 , G01N33/68 , G01N33/50 , B01L3/00 , G01N33/543 , G01N33/569 , G01N33/58
CPC分类号： G01N33/5302 , B01L3/502 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/025 , B01L2200/10 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2300/0877 , B01L2300/0883 , B01L2300/123 , B01L2300/18 , B01L2400/0406 , B01L2400/0481 , G01N33/5091 , G01N33/54386 , G01N33/569 , G01N33/56972 , G01N33/582 , G01N33/68 , G01N33/6872 , G01N2333/70535 , G01N2333/70596 , G01N2800/26
摘要： The present invention provides kits, apparatus and methods for determining a biological condition in a mammalian subject, the method includes incubating a specimen from a patient with at least one composition in a kit for a predetermined period of time to form at least one reaction product, when the subject has said biological condition, and receiving an indication of the at least one reaction product responsive to at least one reporter element in the kit thereby providing the indication of the biological condition in the subject.
-
67.发明申请公开(公告)号：US20180141045A1
公开(公告)日：2018-05-24
申请号：US15876749
申请日：2018-01-22
发明人： John A. Verrant , Niten V. Lalpuria , Igor Nikonorov , Darryn W. Unfricht , Benjamin Ports , Stephen C. Wardlaw , Robert A. Levine , Robert Holt , Kyle Hukari
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/5027 , B01L3/50273 , B01L2200/027 , B01L2300/0861
摘要： A biological fluid analysis cartridge is provided. In certain embodiments, the cartridge includes a base plate extending between a sample handling portion and an analysis chamber portion. A handling upper panel is attached to the base plate within the sample handling portion. A collection port is at least partially formed with the handling upper panel. An initial channel and a secondary channel are formed between the handling upper panel and the base plate. The collection port and initial and secondary channels are in fluid communication with one another. A chamber upper panel is attached to the base plate within the analysis chamber portion. At least one analysis chamber is formed between the chamber upper panel and the base plate. The secondary channel and the analysis chamber are in fluid communication with one another.
-
68.发明授权公开(公告)号：US09976174B2
公开(公告)日：2018-05-22
申请号：US15077182
申请日：2016-03-22
IPC分类号： C12M1/00 , C12Q1/68 , G01N21/13 , G01N21/25 , G01N21/64 , G02B21/34 , G01N35/10 , B01L9/00 , G01N35/00 , B01L3/00 , B01L7/00
CPC分类号： C12Q1/6837 , B01L3/5027 , B01L7/52 , B01L9/52 , B01L9/527 , B01L2300/0654 , B01L2300/0816 , B01L2300/0822 , B01L2300/0877 , C12Q1/6869 , G01N21/13 , G01N21/253 , G01N21/6452 , G01N35/04 , G01N35/1095 , G01N2035/00356 , G01N2035/00752 , G01N2035/0091 , G01N2201/025 , G02B21/34
摘要： Method includes positioning a first carrier assembly on a system stage. The carrier assembly includes a support frame having an inner frame edge that defines a window of the support frame. The first carrier assembly includes a first substrate that is positioned within the window and surrounded by the inner frame edge. The first substrate has a sample thereon. The method includes detecting optical signals from the sample of the first substrate. The method also includes replacing the first carrier assembly on the system stage with a second carrier assembly on the system stage. The second carrier assembly includes the support frame and an adapter plate held by the support frame. The second carrier assembly has a second substrate held by the adapter plate that has a sample thereon. The method also includes detecting optical signals from the sample of the second substrate.
-
公开(公告)号：US20180127594A1
公开(公告)日：2018-05-10
申请号：US15804809
申请日：2017-11-06
IPC分类号： C09D5/00 , C09D5/16 , H01L31/0236 , A61L15/24 , A61L15/34 , A61L15/42 , A61L15/46 , A61L27/28 , A61L27/34 , A61L27/50 , A61L33/00 , A61L33/06 , C10M105/56 , F28F13/18 , F28F19/02 , B01L3/00 , C08L27/12 , B65D25/14 , F15D1/10 , F15D1/02 , F01D25/18 , B05D5/00 , B05D3/00 , C10M105/54 , B01D69/02 , B05D5/08 , B63B59/04 , B64D15/00 , C02F1/44 , D06M13/00 , E04B1/92 , F01D25/02 , F16L57/00 , H01L31/0216
CPC分类号： C09D5/00 , A61L15/24 , A61L15/34 , A61L15/42 , A61L15/46 , A61L27/28 , A61L27/34 , A61L27/50 , A61L33/0094 , A61L33/064 , A61L2400/12 , B01D69/02 , B01D2325/06 , B01L3/5027 , B01L2300/16 , B05D3/002 , B05D5/00 , B05D5/083 , B63B59/04 , B64D15/00 , B65D25/14 , C02F1/44 , C09D5/16 , C09D5/1656 , C09D5/1681 , C09D5/1693 , C10M105/54 , C10M105/56 , D06M13/00 , E04B1/92 , F01D25/02 , F01D25/18 , F15D1/02 , F15D1/10 , F16L57/00 , F28F13/185 , F28F19/02 , F28F2245/04 , G02B1/14 , H01L31/02167 , H01L31/0236 , Y02W10/37 , Y10T428/24355 , Y10T428/24364 , C08L27/12
摘要： The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). Slippery liquid-infused porous surfaces outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (
-
公开(公告)号：US09962701B2
公开(公告)日：2018-05-08
申请号：US15386515
申请日：2016-12-21
申请人： Qiagen Sciences, LLC
IPC分类号： B01L3/00 , G01N35/08 , G01N35/00 , B01D69/02 , G01N35/10 , C12N15/10 , B01J19/00 , G01N15/14 , C12M3/06 , B01L7/00
CPC分类号： B01L3/502761 , B01D69/02 , B01D2325/06 , B01D2325/08 , B01J19/0046 , B01L3/5027 , B01L3/50273 , B01L3/50857 , B01L7/52 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/0877 , B01L2300/0893 , B01L2300/1822 , B01L2400/0409 , B01L2400/0487 , B01L2400/086 , C12M23/16 , C12N15/1017 , G01N15/1484 , G01N35/08 , G01N35/1011 , G01N2015/149
摘要： A flowcell for a sequencing instrument. The flowcell includes a fluid inlet, a fluid outlet, a flow channel formed between an at least partially transparent cover and a base and fluidly connecting the fluid inlet to the fluid outlet, and a capture substrate provided in the flow channel. The capture substrate includes microretainers configured to each receive a single microspot having a microspot diameter, and microretainer is separated from adjacent microretainers by an interstitial gap distance that is equal to or greater than the microspot diameter. A particle separator may be fluidly connected to the flowcell. The particle separator may include a microfluidic channel having an array of micropillars to transfer a plurality of the microspots to a loading buffer that may be delivered to the flowcell.
-
-
-
-
-
-
-
-
-
搜索结果
5633 条记录 (耗时 0.042 秒)
