公开(公告)号：US09907976B2

公开(公告)日：2018-03-06

申请号：US14131564

申请日：2012-07-09

申请人： Frederic A. Bourke, Jr. ,  Harold Walder ,  Zakaryae Fathi ,  Michael J. Therien ,  Mark W. Dewhirst ,  Ian N. Stanton ,  Jennifer Ann Ayres ,  Diane Renee Fels ,  Joseph A. Herbert

发明人： Frederic A. Bourke, Jr. ,  Harold Walder ,  Zakaryae Fathi ,  Michael J. Therien ,  Mark W. Dewhirst ,  Ian N. Stanton ,  Jennifer Ann Ayres ,  Diane Renee Fels ,  Joseph A. Herbert

IPC分类号： A61N5/06 ,  C08F2/52 ,  C08J3/28 ,  A61K41/00 ,  A61N5/10

CPC分类号： A61N5/062 ,  A61K41/0085 ,  A61N5/0622 ,  A61N5/1077 ,  A61N2005/0661 ,  A61N2005/1091 ,  A61N2005/1098

摘要： A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and a plurality of energy-emitting particles in the medium which, upon radiation from the x-ray source, radiate at a first lower energy than the x-ray source to interact with at least one photoactivatable agent in the medium. The method introduces the plurality of energy-emitting particles into the medium, radiates the energy-emitting particles in the medium with x-rays generated from a peak applied cathode voltage at or below 105 kVp; and emits a lower energy than the x-ray source to interact with the medium or with at least one photoactivatable agent in the medium.

公开(公告)号：US20170190166A1

公开(公告)日：2017-07-06

申请号：US15464913

申请日：2017-03-21

申请人： IMMUNOLIGHT, LLC.

发明人： Zakaryae FATHI

IPC分类号： B32B38/00 ,  C09J11/04 ,  C09J5/04 ,  C09J133/12 ,  B32B37/00 ,  B32B37/12

CPC分类号： B32B38/0008 ,  B32B37/0046 ,  B32B37/12 ,  B32B2037/1253 ,  B32B2310/0881 ,  C08K3/00 ,  C08K3/22 ,  C08K2003/2244 ,  C09J5/00 ,  C09J5/04 ,  C09J11/04 ,  C09J133/12 ,  C09J157/00 ,  C09J2205/31 ,  C09J2433/00 ,  C08K5/005

摘要： A reactive polymer composition is provided, containing a (co)polymer that forms one or more reactive moities, either directly or indirectly, upon application of an ionizing radiation; and a multifunctional curing coagent, along with systems and methods for bonding substrates to one another using such a composition.

公开(公告)号：US09682146B2

公开(公告)日：2017-06-20

申请号：US14450756

申请日：2014-08-04

申请人： Immunolight, LLC

发明人： Frederic A. Bourke, Jr.

IPC分类号： A61K31/37 ,  A61K35/12 ,  A61K31/35 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61K41/00 ,  A61K45/06 ,  A61K31/714 ,  A61K47/02 ,  A61F7/00 ,  A61H23/00 ,  A61K31/366 ,  A61N2/02 ,  A61N5/06 ,  A61N5/10

CPC分类号： A61K41/0071 ,  A61F7/00 ,  A61H23/00 ,  A61K31/35 ,  A61K31/366 ,  A61K31/37 ,  A61K31/714 ,  A61K41/00 ,  A61K41/0066 ,  A61K41/008 ,  A61K45/06 ,  A61K47/02 ,  A61N2/02 ,  A61N5/062 ,  A61N5/10 ,  A61N2005/0656 ,  A61N2005/1089 ,  A61N2005/1098 ,  A61K2300/00

摘要： Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.

公开(公告)号：US09649832B2

公开(公告)日：2017-05-16

申请号：US14593049

申请日：2015-01-09

申请人： Immunolight, LLC ,  Duke University

发明人： Zakaryae Fathi ,  James Clayton ,  Harold Walder ,  Frederic A. Bourke, Jr. ,  Ian Stanton ,  Jennifer Ayres ,  Joshua T. Stecher ,  Michael Therien ,  Eric Toone ,  Dave Gooden ,  Mark Dewhirst ,  Joseph A. Herbert ,  Diane Fels ,  Katherine S. Hansen

IPC分类号： B32B38/00 ,  C09J4/00 ,  C09J133/08 ,  B41J2/175 ,  C08K3/00 ,  A61B17/00 ,  A61L24/06 ,  B32B37/12 ,  B32B37/18

CPC分类号： H01L24/83 ,  A61B17/0057 ,  A61L24/06 ,  B32B3/266 ,  B32B7/14 ,  B32B9/04 ,  B32B37/1284 ,  B32B37/18 ,  B32B38/0008 ,  B32B2037/1253 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  B41J2/17559 ,  C08K3/00 ,  C09J4/00 ,  C09J9/02 ,  C09J11/04 ,  C09J11/06 ,  C09J133/08 ,  C09K11/02 ,  C09K11/7769 ,  C09K11/777 ,  H01L23/5226 ,  H01L24/32 ,  H01L25/0657 ,  H01L25/50 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2224/73253 ,  H01L2224/73265 ,  H01L2224/83192 ,  H01L2224/83855 ,  H01L2224/92125 ,  H01L2225/06524 ,  H01L2225/06589 ,  H01L2924/07811 ,  H01L2924/1461 ,  H01L2924/15311 ,  Y10T428/2852 ,  H01L2924/00014 ,  H01L2924/00

摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.

公开(公告)号：US09526913B2

公开(公告)日：2016-12-27

申请号：US14168795

申请日：2014-01-30

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Tuan Vo-Dinh ,  Jonathan P. Scaffidi ,  Venkata Gopal Reddy Chada ,  Benoit Lauly ,  Yan Zhang ,  Molly K. Gregas ,  Ian Nicholas Stanton ,  Joshua T. Stecher ,  Michael J. Therien ,  Frederic A. Bourke, Jr. ,  Harold Walder ,  Zak Fathi ,  Jennifer A. Ayres ,  Zhenyuan Zhang ,  Joseph H. Simmons ,  Stephen John Norton

IPC分类号： A61N5/06 ,  A61K49/00 ,  A61L2/08 ,  A61N1/40 ,  A61N5/02

CPC分类号： A61N5/062 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/481 ,  A61K41/0042 ,  A61K41/0052 ,  A61K41/0061 ,  A61K49/0039 ,  A61L2/0047 ,  A61L2/08 ,  A61L2202/21 ,  A61L2202/22 ,  A61M5/007 ,  A61N1/406 ,  A61N5/02 ,  A61N5/0601 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/0624 ,  A61N5/10 ,  A61N2005/063 ,  A61N2005/0656 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  A61N2005/1098

摘要： A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light, and a metallic structure attached to the phosphorescent material. The metallic structure has a surface plasmon resonance which resonates at a frequency which spectrally overlaps with one or more frequencies of the emitted light.

摘要翻译： 一种用于增强介质内发射光的基于纳米颗粒的系统。 基于纳米颗粒的系统包括磷光材料，其在激活时产生发射的光，以及附着到磷光材料的金属结构。 金属结构具有表面等离子体共振，其以与所发射的光的一个或多个频率光谱重叠的频率谐振。

公开(公告)号：US20160362534A1

公开(公告)日：2016-12-15

申请号：US15183110

申请日：2016-06-15

申请人： Immunolight, LLC.

发明人： Zakaryae FATHI ,  John PACANOVSKY ,  Frederic A. BOURKE, JR.

IPC分类号： C08J11/10 ,  C08J7/12

CPC分类号： C08J11/10 ,  B32B7/04 ,  B32B38/10 ,  B32B43/006 ,  C08J2321/00 ,  Y02W30/702 ,  Y10T156/1153 ,  Y10T156/1917

摘要： A method is provided for de-bonding objects contained in an article at an interface between the objects, wherein the objects are joined at the interface through an intermediate layer, which involves applying energy from a radiation source, wherein the energy is sufficient to cause destruction of bonds within the intermediate layer; and separating the two objects from one another.

摘要翻译： 提供了一种用于将包含在物品中的物体去粘合在物体之间的界面处的物体的方法，其中物体在界面处通过中间层连接，该中间层涉及从辐射源施加能量，其中能量足以引起破坏 的中间层内的键; 并将两个物体彼此分开。

公开(公告)号：US20160325111A1

公开(公告)日：2016-11-10

申请号：US15151642

申请日：2016-05-11

申请人： IMMUNOLIGHT, LLC ,  DUKE UNIVERSITY

发明人： Frederic A. BOURKE, JR. ,  Tuan VO-DINH ,  Harold WALDER

IPC分类号： A61N5/06 ,  A61N5/02 ,  A61N5/10 ,  A61K41/00 ,  A61K47/48

CPC分类号： A61N5/062 ,  A61K41/0057 ,  A61K41/0061 ,  A61K47/6923 ,  A61N5/022 ,  A61N5/0618 ,  A61N5/0622 ,  A61N5/10 ,  A61N2005/0642 ,  A61N2005/0659 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1098

摘要： Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The methods may further be performed by application of an initiation energy to a subject in situ to activate a pharmaceutical agent directly or via an energy modulation agent, optionally in the presence of one or more plasmonics active agents, thus producing an effect on or change to the target structure. Kits containing products or compositions formulated or configured and systems for use in practicing these methods.

摘要翻译： 用于修饰介导或与生物活性相关的靶结构的产物，组合物，系统和方法，包括治疗由病毒，细胞，亚细胞结构介导或与靶结构相关的疾病，病症或疾病 或胞外结构。 所述方法可以通过向受试者施加起始能量以非侵入性方式原位进行，从而直接或经由调节剂产生对靶结构的作用或改变。 所述方法还可以通过向受试者原位施加引发能量来直接或经由能量调节剂活化药剂，任选地在存在一种或多种等离子体激元活性剂的情况下进行，从而产生效果或改变 目标结构。 包含配制或配置的产品或组合的套件以及用于实施这些方法的系统。

公开(公告)号：US09358292B2

公开(公告)日：2016-06-07

申请号：US11935655

申请日：2007-11-06

申请人： Frederic A. Bourke, Jr.

发明人： Frederic A. Bourke, Jr.

IPC分类号： A61K31/37 ,  A61K35/12 ,  A61K31/35 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61K41/00 ,  A61K45/06 ,  A61K31/714 ,  A61K47/02 ,  A61F7/00 ,  A61H23/00 ,  A61K31/366 ,  A61N2/02 ,  A61N5/06 ,  A61N5/10

CPC分类号： A61K41/0071 ,  A61F7/00 ,  A61H23/00 ,  A61K31/35 ,  A61K31/366 ,  A61K31/37 ,  A61K31/714 ,  A61K41/00 ,  A61K41/0066 ,  A61K41/008 ,  A61K45/06 ,  A61K47/02 ,  A61N2/02 ,  A61N5/062 ,  A61N5/10 ,  A61N2005/0656 ,  A61N2005/1089 ,  A61N2005/1098 ,  A61K2300/00

摘要： Methods for the treatment of a cell proliferation disorder in a subject, involving: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of effecting a predetermined cellular change when activated, either alone or in combination with at least one energy modulation agent; and (2) applying an initiation energy from an initiation energy source to the subject, wherein the applying activates the activatable agent in situ, thus causing the predetermined cellular change to occur, wherein the predetermined cellular change treats the cell proliferation disorder, preferably by causing an increase or decrease in rate of cell proliferation, and a kit for performing the method, a computer implemented system for performing the method, a pharmaceutical composition useful in the method and a method for causing an autovaccine effect in a subject using the method.

公开(公告)号：US09278331B2

公开(公告)日：2016-03-08

申请号：US14635677

申请日：2015-03-02

申请人： IMMUNOLIGHT, LLC.

发明人： Frederic A. Bourke, Jr.

IPC分类号： B01J19/12

CPC分类号： A61N5/10 ,  A23L2/50 ,  A23L3/26 ,  A23L3/263 ,  A23L3/28 ,  A23L5/32 ,  A23V2002/00 ,  A61K41/0057 ,  A61K41/0066 ,  A61L2/0011 ,  A61L2/0047 ,  A61L2/0076 ,  A61L2/082 ,  A61L2/088 ,  A61L2/10 ,  A61L2/16 ,  A61L2202/21 ,  A61L2202/22 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/1098 ,  B01J19/082 ,  B01J19/085 ,  B01J19/12 ,  B01J19/123 ,  B01J19/125 ,  B01J19/127 ,  B01J19/128 ,  B01J23/50 ,  B01J23/52 ,  B01J31/0275 ,  B01J31/2295 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/004 ,  B01J37/0072 ,  B01J37/0221 ,  B01J2219/0877 ,  B01J2219/0879 ,  B01J2219/0892 ,  B01J2219/1203 ,  B01J2231/005 ,  B01J2531/005 ,  B01J2531/008 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C02F1/30 ,  C02F1/302 ,  C02F1/305 ,  C02F1/307 ,  C02F1/32 ,  C02F1/725 ,  C02F2305/10 ,  C08J3/24 ,  C08J3/28 ,  C08J7/18 ,  C08J2300/00 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  C09J2205/31 ,  C12H1/06 ,  G02B5/008 ,  G21K5/00 ,  Y02W10/37 ,  Y10S977/774 ,  Y10S977/777 ,  Y10S977/896 ,  Y10S977/915 ,  Y10T156/10

摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

公开(公告)号：US09005406B2

公开(公告)日：2015-04-14

申请号：US14157039

申请日：2014-01-16

申请人： Immunolight, LLC.

发明人： Frederic A. Bourke, Jr.

IPC分类号： B01J19/12 ,  B01J19/08 ,  A61N5/06 ,  A23L3/26 ,  A61L2/00 ,  C02F1/30 ,  C02F1/72 ,  A61L2/08 ,  A61L2/10 ,  A61L2/16 ,  C08J3/28 ,  G21K5/00 ,  A23L1/025 ,  C02F1/32 ,  A61K41/00 ,  A61N5/10 ,  B82Y20/00

CPC分类号： A61N5/10 ,  A23L2/50 ,  A23L3/26 ,  A23L3/263 ,  A23L3/28 ,  A23L5/32 ,  A23V2002/00 ,  A61K41/0057 ,  A61K41/0066 ,  A61L2/0011 ,  A61L2/0047 ,  A61L2/0076 ,  A61L2/082 ,  A61L2/088 ,  A61L2/10 ,  A61L2/16 ,  A61L2202/21 ,  A61L2202/22 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/1098 ,  B01J19/082 ,  B01J19/085 ,  B01J19/12 ,  B01J19/123 ,  B01J19/125 ,  B01J19/127 ,  B01J19/128 ,  B01J23/50 ,  B01J23/52 ,  B01J31/0275 ,  B01J31/2295 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/004 ,  B01J37/0072 ,  B01J37/0221 ,  B01J2219/0877 ,  B01J2219/0879 ,  B01J2219/0892 ,  B01J2219/1203 ,  B01J2231/005 ,  B01J2531/005 ,  B01J2531/008 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C02F1/30 ,  C02F1/302 ,  C02F1/305 ,  C02F1/307 ,  C02F1/32 ,  C02F1/725 ,  C02F2305/10 ,  C08J3/24 ,  C08J3/28 ,  C08J7/18 ,  C08J2300/00 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  C09J2205/31 ,  C12H1/06 ,  G02B5/008 ,  G21K5/00 ,  Y02W10/37 ,  Y10S977/774 ,  Y10S977/777 ,  Y10S977/896 ,  Y10S977/915 ,  Y10T156/10

摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.

摘要翻译： 一种用于产生介质变化的方法和系统。 该方法在介质附近放置至少一种能量调节剂。 该方法对介质施加引发能量。 引发能与能量调节剂相互作用直接或间接产生介质中的变化。 该系统包括引发能量源，其被配置为向介质施加引发能量以激活能量调节剂。