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    Micro fabricated fountain pen apparatus and method for ultra high density biological arrays
    13.
    发明申请
    Micro fabricated fountain pen apparatus and method for ultra high density biological arrays 审中-公开
    用于超高密度生物阵列的微型钢笔设备和方法

    公开(公告)号：US20030148539A1

    公开(公告)日：2003-08-07

    申请号：US10288248

    申请日：2002-11-04

    Applicant: California Institute of Technology

    Inventor： R. Michael van Dam ,  Stephen R. Quake ,  Axel Scherer ,  Matthew O. Reese

    IPC: B01L003/02 ,  G01N001/10

    CPC classification number: B01L3/0244 ,  B01L3/0248 ,  B01L3/0275 ,  B01L3/5085 ,  B01L2200/0642 ,  B01L2300/0838 ,  B01L2300/123 ,  G01N2035/1037 ,  Y10T436/2575

    Abstract: A fluid dispensing system for at least biological applications, e.g., oligonucleotides, peptide nucleic acids (nullPNAnull), proteins, polysaccharides, polypeptides, inorganic solutions, microelectromechanical systems (MEMS), optical sensors, and other applications. The dispensing system includes a fluid dispensing apparatus for applying selected fluids in a predetermined manner to form a plurality of spots based upon one or more of the selected fluids on a surface of a substrate. The apparatus comprises an elongated member having at least a tip portion, which extends from the elongated member. The apparatus also has an etched trench extending along a portion of a length of the elongated member to the tip to form an opening defined on the tip portion and coupled to the etched trench. A flexible region is defined within the elongated member to allow the tip to adjust in position upon contact with the surface of the substrate. A fluid is disposed within the etched trench. The fluid is output through the opening on the tip to form more than one spots on the surface of the substrate.

    Abstract translation: 用于至少生物应用的流体分配系统，例如寡核苷酸，肽核酸（“PNA”），蛋白质，多糖，多肽，无机溶液，微机电系统（MEMS），光学传感器和其它应用。 分配系统包括用于以预定方式施加选定流体以形成基于基底表面上的一种或多种所选流体的多个斑点的流体分配装置。 该装置包括细长构件，该细长构件至少具有从细长构件延伸的尖端部分。 该设备还具有沿着细长构件的长度的一部分延伸到尖端的蚀刻沟槽，以形成限定在尖端部分上并连接到蚀刻沟槽的开口。 柔性区域限定在细长构件内，以允许尖端在与基底的表面接触时调节位置。 流体被设置在蚀刻沟槽内。 流体通过尖端上的开口输出，以在基底表面上形成多于一个点。

    Microfluidic devices and methods of use
    14.
    发明申请
    Microfluidic devices and methods of use 有权
    微流体装置及使用方法

    公开(公告)号：US20020127736A1

    公开(公告)日：2002-09-12

    申请号：US09970122

    申请日：2001-10-02

    Applicant: California Institute of Technology

    Inventor： Hou-Pu Chou ,  Anne Y. Fu ,  Stephen R. Quake

    IPC: B01L003/00

    CPC classification number: F04B43/00 ,  A61M2206/22 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/123 ,  B01L2400/0418 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/084 ,  F04B11/00 ,  F04B19/006 ,  F04B43/043 ,  G01N30/6095 ,  G01N2015/1081 ,  G01N2015/149 ,  G01N2030/205 ,  G01N2030/322 ,  Y10T436/2575

    Abstract: A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a junction. Based upon an identity of the entity determined in the detection region, a waste or collection valve located on opposite branches of the flow channel at the junction are actuated, thereby routing the entity to either a waste pool or a collection pool. A damper structure may be located between the pump and the junction. The damper reduces the amplitude of oscillation pressure in the flow channel due to operation of the pump, thereby lessening oscillation in velocity of the entity during sorting process. The microfluidic device may be formed in a block of elastomer material, with thin membranes of the elastomer material deflectable into the flow channel to provide pump or valve functionality.

    Abstract translation: 微流体装置包括泵，阀和流体振荡阻尼器。 在用于排序的装置中，实体通过泵通过检测区域的流动通道流到结。 基于在检测区域中确定的实体的身份，致动位于连接处的流动通道的相对分支上的废物或收集阀，从而将该实体路由到废物池或收集池。 阻尼器结构可以位于泵和接头之间。 阻尼器由于泵的操作而减小了流动通道中的振荡压力的振幅，从而减少了分离过程中实体的速度振荡。 微流体装置可以形成为弹性体材料块，弹性体材料的薄膜可偏转到流动通道中以提供泵或阀的功能。

    Microfabricated cell sorter
    15.
    发明申请
    Microfabricated cell sorter 有权
    微型细胞分选机

    公开(公告)号：US20020005354A1

    公开(公告)日：2002-01-17

    申请号：US09928590

    申请日：2001-08-13

    Applicant: California Institute of Technology

    Inventor： Charles F. Spence ,  Anne Y. Fu ,  Stephen R. Quake ,  Frances H. Arnold

    IPC: C12M001/36 ,  C12M001/00 ,  C12M001/34 ,  C12M001/42 ,  G01N027/26 ,  G01N027/447

    CPC classification number: G01N27/26 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0864 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0418 ,  B01L2400/0421 ,  B01L2400/0424 ,  B01L2400/0454 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  G01N15/14 ,  G01N2015/149

    Abstract: The invention provides a microfabricated device for sorting cells based on a desired characteristic, for example, reporter-labeled cells can be sorted by the presence or level of reporter on the cells. The device includes a chip having a substrate into which is microfabricated at least one analysis unit. Each analysis unit includes a main channel, having a sample inlet channel, typically at one end, and a detection region along a portion of its length. Adjacent and downstream from the detection region, the main channel has a discrimination region or branch point leading to at least two branch channels. The analysis unit may further include additional inlet channels, detection points, branch points, and branch channels as desired. A stream containing cells is passed through the detection region, such that on average one cell occupies the detection region at a given time. The cells can be sorted into an appropriate branch channel based on the presence or amount of a detectable signal such as an optical signal, with or without stimulation, such as exposure to light in order to promote fluorescence.

    Abstract translation: 本发明提供了一种用于基于所需特征分选细胞的微制造装置，例如，报道分子标记的细胞可以通过细胞上报告物的存在或水平进行分选。 该装置包括具有基板的芯片，微基板将至少一个分析单元微加工。 每个分析单元包括主通道，具有通常在一端的样品入口通道和沿其长度的一部分的检测区域。 相邻和下游的检测区域，主通道具有通向至少两个分支通道的识别区域或分支点。 分析单元还可以根据需要进一步包括额外的入口通道，检测点，分支点和分支通道。 包含细胞的流通过检测区域，使得平均一个细胞在给定时间占据检测区域。 基于可检测信号（例如光信号）的存在或量，可以将细胞分类到适当的分支通道中，具有或不具有刺激，例如暴露于光以促进荧光。

    Non-metric tool for predicting gene relationships from expression data
    17.
    发明申请
    Non-metric tool for predicting gene relationships from expression data 失效
    用于从表达数据预测基因关系的非度量工具

    公开(公告)号：US20030152969A1

    公开(公告)日：2003-08-14

    申请号：US10289141

    申请日：2002-11-05

    Applicant: California Institute of Technology

    Inventor： Stephen R. Quake ,  R. Michael van Dam ,  James P. Brody ,  Rebecca Shafee

    IPC: C12Q001/68 ,  G06F019/00 ,  G01N033/48 ,  G01N033/50

    CPC classification number: G06F19/20 ,  G06F17/15 ,  G06F19/24

    Abstract: Techniques for processing gene expression data and predicting gene relationships are provided. More specifically, a method for processing gene expression ratios may include discretizing a first expression ratio for a first gene and a second expression ratio for a second gene for each of a plurality of experiments into one of three indications, calculating the probability that the combination of the discretized expression ratios for each of the plurality of experiments arises by random chance, and determining whether the first gene and the second gene are related.

    Abstract translation: 提供了处理基因表达数据和预测基因关系的技术。 更具体地，用于处理基因表达比率的方法可以包括将用于第一基因的第一表达比例和第二基因的第二表达比例分离为多个实验中的每一个进行三个指示之一，计算组合 多个实验中的每一个的离散化表达比均由随机机会产生，并且确定第一基因和第二基因是否相关。

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