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    Device for amplifying target nucleic acid
    12.
    发明授权
    Device for amplifying target nucleic acid 有权
    用于扩增靶核酸的装置

    公开(公告)号：US08822183B2

    公开(公告)日：2014-09-02

    申请号：US13764970

    申请日：2013-02-12

    Applicant: Applied Biosystems, LLC ,  The United States of America, as represented by the Secretary of the Department of Health and Human Services

    Inventor： James F. Brown ,  Jonathan E. Silver

    IPC: C12P19/34 ,  C12M1/00 ,  C12Q1/68 ,  C40B60/14 ,  B01L3/00

    CPC classification number: C12Q1/6806 ,  B01J2219/00317 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00722 ,  B01L3/5027 ,  B01L3/5085 ,  B01L3/50851 ,  B01L3/5088 ,  B01L2200/06 ,  B01L2200/0642 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2400/0409 ,  C07H21/00 ,  C12Q1/6844 ,  C12Q1/686 ,  C40B60/14 ,  Y10S436/805 ,  Y10S436/809 ,  Y10T436/2575

    Abstract: A device for amplifying target nucleic acid in a sample can include a planar fluidic assembly including a transparent substrate, a porous material layer on a surface of the transparent substrate, and a cover over the porous material layer and sealingly affixed to the substrate. The cover may be spaced from the porous material layer and a flow channel defined between the porous material layer and the cover. The flow channel may have a uniform cross-section from a first end to a second end. The assembly can further include an inlet in flow communication with the first end of the flow channel to introduce sample containing target nucleic acid into the flow channel, an outlet in flow communication with the second end of the flow channel, and a plurality of nucleic acid primers retained by the porous material layer at discrete regions along and within the flow channel, each of the plurality of nucleic acid primers being complementary to a portion of the target nucleic acid in the sample to enable a primer-based amplification reaction of the target nucleic acid. The porous material layer may be configured to retain, at the discrete regions and during a primer-based amplification reaction, sample introduced to the flow channel and amplified product of the amplification reaction.

    Abstract translation: 用于放大样品中的靶核酸的装置可以包括平面流体组件，其包括透明基板，在透明基板的表面上的多孔材料层，以及覆盖在多孔材料层上并密封地固定到基板上的盖。 盖可以与多孔材料层隔开并且在多孔材料层和盖之间限定流动通道。 流动通道可以具有从第一端到第二端的均匀的横截面。 组件还可以包括与流动通道的第一端流动连通的入口，以将含有靶核酸的样品引入流动通道，与流动通道的第二端流动连通的出口和多个核酸 由多孔材料层在沿着流动通道内部和内部的离散区域保留的引物，多个核酸引物中的每一个与样品中目标核酸的一部分互补，以使靶核酸的引物扩增反应 酸。 多孔材料层可以被配置为在离散区域和基于引物的扩增反应期间保留引入流动通道的样品和扩增反应的扩增产物。

    Dialysis cell and tray for dialysis cells
    13.
    发明授权
    Dialysis cell and tray for dialysis cells 有权
    透析池和透析池托盘

    公开(公告)号：US08808541B2

    公开(公告)日：2014-08-19

    申请号：US12074479

    申请日：2008-03-03

    Applicant: Marwan Nasralla

    Inventor： Marwan Nasralla

    IPC: B01D61/26 ,  B01D63/00 ,  B01D35/30 ,  G01N1/40 ,  B01D61/28 ,  B01L3/00

    CPC classification number: G01N1/4005 ,  B01D61/28 ,  B01L3/502 ,  G01N2001/4016 ,  Y10S436/809

    Abstract: A dialysis cell is provided for the measurement of free thyroxine. The dialysis cell preferably includes a polyhedral housing including a top, a bottom and four sides. The dialysis cell is made up of a buffer portion and serum portion. The buffer portion includes a cavity and the serum portion includes a cavity which, when the buffer portion and serum portion are assembled together, form a central chamber. The central chamber is divided by a vertically aligned dialysis membrane held in place by two O-rings. Buffer is introduced into the dialysis cell's buffer portion through a buffer inlet extending from the dialysis cell's top side to the buffer portion's cavity. Similarly, serum is introduced into the serum portion through an inlet which extends from an opening formed on the dialysis cell's top to the serum portion's cavity.

    Abstract translation: 提供了一种用于测量游离甲状腺素的透析池。 透析池优选地包括多面体壳体，其包括顶部，底部和四个侧面。 透析池由缓冲部分和血清部分组成。 缓冲部分包括空腔，血清部分包括空腔，当缓冲部分和血清部分组装在一起时，形成中心室。 中央室由两个O形环保持在适当位置的垂直排列的透析膜分隔开。 将缓冲液通过从透析池顶部延伸到缓冲部分腔的缓冲入口引入透析池的缓冲部分。 类似地，血清通过从透析池顶部上形成的开口延伸到血清部分腔的入口引入血清部分。

    LATERAL FLOW ASSAY SYSTEMS AND METHODS
    19.
    发明申请
    LATERAL FLOW ASSAY SYSTEMS AND METHODS 有权
    侧流测量系统和方法

    公开(公告)号：US20140004624A1

    公开(公告)日：2014-01-02

    申请号：US14019166

    申请日：2013-09-05

    Applicant: Alverix, Inc.

    Inventor： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

    IPC: G01N21/17

    CPC classification number: G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

    Abstract: In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

    Abstract translation: 一方面，诊断测试系统包括壳体，读取器和数据分析器。 壳体包括用于接收测试条的端口。 读取器从暴露于光学检查的检测区域的区域的局部区域获得可分离的光强度测量值，其中每个局部区域的特征在于至少一个小于第一维度的表面尺寸。 数据分析器识别从至少一个测试区域获得的光强度测量结果中的一个，并从所识别的光强测量中计算至少一个参数。 在另一方面，读取器从检测区域的暴露表面区域的多个对应区域中的每一个获得相应的一组光强度测量值，并且数据分析器从至少一个光强度测量集合中计算至少一个参数 。

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