公开(公告)号：US20150366461A1

公开(公告)日：2015-12-24

申请号：US14605576

申请日：2015-01-26

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Hakan Oral ,  Fred Morady

IPC: A61B5/01 ,  A61B18/12 ,  A61B1/00 ,  A61B5/00 ,  G01J5/08 ,  G01J5/04

CPC classification number: A61B5/01 ,  A61B1/00096 ,  A61B1/273 ,  A61B5/015 ,  A61B5/412 ,  A61B5/7278 ,  A61B18/0218 ,  A61B18/12 ,  A61B18/1206 ,  A61B18/18 ,  A61B2017/00057 ,  A61B2017/00061 ,  A61B2017/00084 ,  A61B2018/00011 ,  A61B2018/00488 ,  A61B2018/0212 ,  A61B2562/0271 ,  G01J5/0022 ,  G01J5/0025 ,  G01J5/02 ,  G01J5/0215 ,  G01J5/04 ,  G01J5/047 ,  G01J5/08 ,  G01J5/0803 ,  G01J5/0806 ,  G01J5/0809 ,  G01J5/0818 ,  G01J5/0843 ,  G01J5/0846 ,  G01J2005/0081

Abstract: An endoscopic system may include an endoscopic device and a control apparatus. The device may include a housing membrane having a distal end and a transparent outer layer around a periphery of the housing membrane and extending longitudinally from the distal end to define a side volume of interest, and an optical infrared sensor array comprising infrared sensors extending longitudinally along and circumferentially about a longitudinal axis of the device to detect infrared radiation over the side volume. The control apparatus may include a processor and a computer-readable medium having computer-executable instructions that cause the processor to, determine temperature data for the side volume in response to infrared data from the infrared sensor array, determine if the temperature data is in a temperature region of concern in a vessel, and provide a temperature control signal to a subsystem to instruct the subsystem to reduce temperature in the vessel.

Abstract translation: 内窥镜系统可以包括内窥镜装置和控制装置。 该装置可以包括壳体膜，其具有围绕壳体膜的周边的远端和透明外层，并且从远端纵向延伸以限定感兴趣的侧体积，以及包括沿着纵向延伸的红外传感器的光学红外传感器阵列 并围绕装置的纵向轴线周向地围绕侧体积检测红外辐射。 控制装置可以包括处理器和具有计算机可执行指令的计算机可读介质，其使处理器响应于来自红外传感器阵列的红外数据来确定侧面体积的温度数据，确定温度数据是否在 并且向子系统提供温度控制信号以指示子系统降低容器中的温度。

公开(公告)号：US09174065B2

公开(公告)日：2015-11-03

申请号：US12902133

申请日：2010-10-11

Applicant: Michael Gertner

Inventor： Michael Gertner

IPC: A61B5/055 ,  A61N2/00 ,  A61B5/00 ,  A61B8/00 ,  A61B8/06 ,  A61B8/08 ,  A61N5/06 ,  A61N7/00 ,  A61N7/02 ,  A61B17/32 ,  A61B18/18 ,  A61N5/00 ,  A61B18/14 ,  A61N1/05 ,  A61B5/0225 ,  A61B6/03 ,  A61B19/00 ,  A61B18/00 ,  A61B6/00

CPC classification number: A61N2/006 ,  A61B5/0225 ,  A61B5/055 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/4047 ,  A61B5/4052 ,  A61B5/412 ,  A61B5/4528 ,  A61B5/4839 ,  A61B5/489 ,  A61B5/4893 ,  A61B6/03 ,  A61B6/032 ,  A61B6/037 ,  A61B6/506 ,  A61B8/00 ,  A61B8/06 ,  A61B8/08 ,  A61B8/4245 ,  A61B8/485 ,  A61B17/320068 ,  A61B18/14 ,  A61B18/18 ,  A61B90/37 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2090/374 ,  A61B2090/3762 ,  A61B2090/378 ,  A61N1/0551 ,  A61N5/00 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/0622 ,  A61N7/00 ,  A61N7/02 ,  A61N2005/063 ,  A61N2007/0026 ,  A61N2007/003 ,  A61N2007/0078

Abstract: In some examples, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some examples, different types of energy sources are utilized singly or combined with one another. In some examples, bioactive agents or devices activated by the energy sources are delivered to the region of interest and the energy is enhanced by such agents or the agents are enhanced by the energy sources.

Abstract translation: 在一些实例中，围绕动脉或通向器官的神经以能量来靶向以校正或调节生理过程。 在一些示例中，不同类型的能量源单独使用或彼此组合使用。 在一些实例中，由能量源激活的生物活性剂或装置被输送到感兴趣的区域，并且能量被这种试剂增强，或者这些试剂被能量源增强。

公开(公告)号：US09144383B2

公开(公告)日：2015-09-29

申请号：US12945576

申请日：2010-11-12

Applicant: Vladimir Pavlovich Zharov

Inventor： Vladimir Pavlovich Zharov

IPC: A61B8/00 ,  A61B6/00 ,  A61B5/00 ,  A61K49/22 ,  B03C1/28 ,  B03C1/30 ,  A61B8/08 ,  A61B18/18 ,  A61B18/20 ,  G01N15/14

CPC classification number: A61B5/0059 ,  A61B5/0095 ,  A61B5/412 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B8/08 ,  A61B8/481 ,  A61B18/1815 ,  A61B18/20 ,  A61K49/22 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/06 ,  B03C2201/26 ,  G01N15/1425 ,  G01N15/1434 ,  G01N15/147 ,  G01N2015/1477

Abstract: A device and methods for the non-invasive manipulation and detection of target objects such as cells, pathogens, microparticles, and nanoparticles in vivo using an external magnetic field are described. In one aspect, a device and method for capturing and detecting intrinsically magnetic target objects or target objects labeled with at least one magnetic particle within the area of interest using an in vivo flow cytometer are described.

Abstract translation: 描述了使用外部磁场在体内非侵入性地操纵和检测诸如细胞，病原体，微粒和纳米颗粒的目标物体的装置和方法。 在一个方面，描述了使用体内流式细胞仪来捕获和检测在目标区域内用至少一个磁性颗粒标记的本征磁性目标物体或目标物体的装置和方法。

公开(公告)号：US09101304B2

公开(公告)日：2015-08-11

申请号：US13000708

申请日：2009-07-02

Applicant: Stefan Lindgren ,  Anders Carlsson ,  Anton Karlsson ,  Henrik Falkén ,  Gerhard Jobst

Inventor： Stefan Lindgren ,  Anders Carlsson ,  Anton Karlsson ,  Henrik Falkén ,  Gerhard Jobst

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495

CPC classification number: A61B5/14532 ,  A61B5/14525 ,  A61B5/14528 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/412

Abstract: A measuring system (100) for continuously measuring body fluid constituents, said measuring system (100) comprising a microdialysis catheter or probe (110) comprising a microdialysis membrane (116) to be placed in a blood stream or in tissue fluid. The measuring system further comprises a flow through sensor (200) for continuously measuring the concentration of substances present in the fluid that has passed the microdialysis membrane (116). The measuring system (100) further comprises a waste container (126).

Abstract translation: 一种用于连续测量体液成分的测量系统（100），所述测量系统（100）包括微透析导管或探针（110），所述微透析导管或探针（110）包括放置在血流或组织液中的微透析膜（116）。 测量系统还包括用于连续测量已经通过微透析膜（116）的流体中存在的物质的浓度的流通传感器（200）。 测量系统（100）还包括废物容器（126）。

公开(公告)号：US09044182B2

公开(公告)日：2015-06-02

申请号：US13804184

申请日：2013-03-14

Applicant: James H. Silver

Inventor： James H. Silver

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/0215 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1486 ,  G01N33/84 ,  A61F2/82

CPC classification number: A61B5/14546 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/14528 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/14735 ,  A61B5/1477 ,  A61B5/14865 ,  A61B5/4076 ,  A61B5/412 ,  A61B5/413 ,  A61B5/4839 ,  A61B5/686 ,  A61B5/6862 ,  A61B5/6876 ,  A61B5/6882 ,  A61B2560/0219 ,  A61B2562/0209 ,  A61F2/82 ,  A61F2250/0001 ,  G01N33/84 ,  Y10T436/177692

Abstract: A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed.

Abstract translation: 公开了一种系统，其将体液提取到用于监测患者流体的物质或性质的反应室。 在一个实施例中，使用泵将体液样品推进过滤器以产生滤液。 另一个泵将滤液推进到反应室中，而另一个泵将反应物进入反应室。 与反应室连通的传感器确定一氧化氮或其代谢产物之一的浓度。 还公开了方法。

公开(公告)号：US20150105634A1

公开(公告)日：2015-04-16

申请号：US14575905

申请日：2014-12-18

Applicant: Edwards Lifesciences Corporation

Inventor： Feras Al Hatib

IPC: A61B5/00 ,  A61B5/024 ,  A61B5/029 ,  A61B8/02 ,  A61B5/0402 ,  A61B5/1455 ,  A61B8/06 ,  A61B5/021 ,  A61B5/0295

CPC classification number: A61B5/7246 ,  A61B5/02 ,  A61B5/021 ,  A61B5/02125 ,  A61B5/02405 ,  A61B5/0285 ,  A61B5/029 ,  A61B5/0295 ,  A61B5/0402 ,  A61B5/14551 ,  A61B5/412 ,  A61B5/7282 ,  A61B8/02 ,  A61B8/065

Abstract: Methods for monitoring cardiovascular conditions, i.e., hyperdynamic circulation, vasodilation, vasoconstriction, or central-to-peripheral arterial pressure decoupling conditions are described. These methods involve measuring a central signal proportional to or a function of the subject's heart activity and a peripheral signal proportional to or a function of a signal related to the central signal. Then calculating a time difference between features in the central and peripheral signals representing the same heart event. The cardiovascular condition is indicated if the time difference is greater or lower than a threshold value, if the time difference is greater or lower than a threshold value over a specified period of time, or if there is a significant statistical change in the times over the specified time period. These methods can alert a user that a subject is experiencing the cardiovascular condition, which can enable a clinician to appropriately provide treatment to the subject.

Abstract translation: 描述了监测心血管疾病，即高动力循环，血管舒张，血管收缩或中枢至外周动脉压力解耦条件的方法。 这些方法涉及测量与被检者的心脏活动成比例的功能或者是与中心信号相关的信号成比例的功能或与其相关的信号的功能的中心信号。 然后计算表示相同心脏事件的中心和外围信号的特征之间的时间差。 如果时间差大于或低于阈值，则指示心血管状况，如果时间差在特定时间段内大于或低于阈值，或者如果在超过指定时间段的时间内存在显着的统计学变化 指定时间段 这些方法可以提醒用户受试者正在经历心血管疾病，这使得临床医生能够适当地向受试者提供治疗。

公开(公告)号：US20150085249A1

公开(公告)日：2015-03-26

申请号：US14551895

申请日：2014-11-24

Applicant: GEELUX HOLDING, LTD.

Inventor： Marcio Marc ABREU

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/16 ,  A61B5/145

CPC classification number: A61B3/10 ,  A61B3/0025 ,  A61B3/0058 ,  A61B3/1241 ,  A61B3/16 ,  A61B3/185 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/031 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14555 ,  A61B5/1486 ,  A61B5/18 ,  A61B5/412 ,  A61B5/416 ,  A61B5/445 ,  A61B5/4839 ,  A61B5/6814 ,  A61B8/06 ,  A61B8/56 ,  A61B2560/0214 ,  A61B2560/0219 ,  A61B2560/0252 ,  A61B2560/0418 ,  A61B2562/0238 ,  A61B2562/12 ,  A61F9/0017 ,  A61F9/0026 ,  G02C7/04 ,  Y02A90/26

Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver. The signal can then be processed, analyzed and stored. Several parameters can be detected including a complete non-invasive analysis of blood components, measurement of systemic and ocular blood flow, measurement of heart rate and respiratory rate, tracking operations, detection of ovulation, detection of radiation and drug effects, diagnosis of ocular and systemic disorders and the like.

Abstract translation: 利用放置在眼睛上的接触装置，以便根据这些物理和化学参数检测身体的物理和化学参数以及化合物的非侵入性递送，其中信号作为电磁波，无线电波， 红外线等。 要检测的参数之一包括使用在结膜和泪液膜中发现的化学变化和化学产物的非侵入性血液分析。 安装在敷设在角膜或眼睛表面上的接触装置中的传感器能​​够评估和测量眼睛中的物理和化学参数，包括非侵入性血液分析。 该系统利用眼罩运动和/或关闭眼罩来启动安装在接触装置中的微型射频敏感传感器。 该信号可以通过电线或遥控的无线电通信到外部放置的接收器。 然后可以处理，分析和存储信号。 可以检测到几个参数，包括血液成分的全面无创分析，全身和眼部血流量的测量，心率和呼吸频率的测量，跟踪操作，排卵检测，辐射检测和药物作用，眼睛和 全身性疾病等。

公开(公告)号：US08936629B2

公开(公告)日：2015-01-20

申请号：US11901299

申请日：2007-08-24

Applicant: Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Thomas Allan Weaver ,  Lowell L. Wood, Jr.

Inventor： Edward S. Boyden ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Dennis J. Rivet ,  Thomas Allan Weaver ,  Lowell L. Wood, Jr.

IPC: A61N5/06 ,  A61B5/00 ,  A61B5/07 ,  A61B18/20 ,  A61N5/10

CPC classification number: A61N5/0624 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0088 ,  A61B5/0091 ,  A61B5/07 ,  A61B5/412 ,  A61B5/4547 ,  A61B18/20 ,  A61N5/01 ,  A61N5/0603 ,  A61N5/10 ,  A61N2005/0626 ,  A61N2005/0663

Abstract: Apparatus, devices, methods, systems, computer programs and computing devices related to autofluorescent imaging and ablation are disclosed.

Abstract translation: 公开了与自发荧光成像和消融相关的装置，装置，方法，系统，计算机程序和计算装置。

公开(公告)号：US20150018758A1

公开(公告)日：2015-01-15

申请号：US14070522

申请日：2013-11-02

Applicant: Michael Sasha John

Inventor： Michael Sasha John

IPC: A61M5/168 ,  A61M5/14 ,  A61M25/00 ,  A61M5/142 ,  A61M5/172

CPC classification number: A61M5/16809 ,  A61B5/14532 ,  A61B5/412 ,  A61M5/1408 ,  A61M5/14276 ,  A61M5/16827 ,  A61M5/172 ,  A61M5/1723 ,  A61M25/00 ,  A61M25/0026 ,  A61M25/003 ,  A61M25/0097 ,  A61M2005/14208 ,  A61M2025/0002 ,  A61M2025/0036 ,  A61M2025/0037 ,  A61M2025/004 ,  A61M2205/3523 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17

Abstract: A drug delivery system provides for controlled mixing of drugs, using flow controllers to guide drugs into single or multiple catheters, enabling a single lumen catheter to dispense multiple drugs, diluting a concentrated drug to provide varying drug concentration, using a buffer fluid to deliver precise amounts of drug or to separate drugs within a catheter, and using a patient's bodily fluid as a diluent or buffer fluid. A drug testing/filler apparatus may be used prior to system use to facilitate filling of multiple reservoirs and may also be used for refilling. The system can provide bolus or continuous delivery and enable the measured delivery of drug to selected distal locations at independent rates. New types of catheter systems, catheter hub assemblies, and uses therefore are also described. New methods for promotion of healthy pregnancy and treatment of a developing fetus are disclosed.

Abstract translation: 药物递送系统提供药物的受控混合，使用流量控制器将药物引导至单个或多个导管，使得单腔导管能够分配多种药物，稀释浓缩的药物以提供不同的药物浓度，使用缓冲液来递送精确的 药物的量或在导管内分开药物，并使用患者的体液作为稀释剂或缓冲液。 可以在系统使用之前使用药物测试/填充装置以便于填充多个储存器，并且还可以用于再填充。 该系统可以提供推注或连续递送，并使得能够以独立的速率测量药物递送到选定的远端位置。 因此，还描述了新型的导管系统，导管毂组件和用途。 公开了促进健康怀孕和治疗发育中的胎儿的新方法。

公开(公告)号：US08911367B2

公开(公告)日：2014-12-16

申请号：US11691424

申请日：2007-03-26

Applicant: Mark Brister ,  Mark Shults ,  Sean Saint ,  James R. Petisce ,  David K. Wong ,  Kum Ming Woo

Inventor： Mark Brister ,  Mark Shults ,  Sean Saint ,  James R. Petisce ,  David K. Wong ,  Kum Ming Woo

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/1473 ,  A61M5/172 ,  A61M5/14 ,  A61M5/168

CPC classification number: A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/412 ,  A61B5/6848 ,  A61B5/6849 ,  A61B2560/0223 ,  A61M5/14 ,  A61M5/16804 ,  A61M5/1723 ,  A61M2230/201

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.