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公开(公告)号：US09649832B2
公开(公告)日：2017-05-16
申请号：US14593049
申请日：2015-01-09
申请人： Immunolight, LLC , Duke University
发明人： Zakaryae Fathi , James Clayton , Harold Walder , Frederic A. Bourke, Jr. , Ian Stanton , Jennifer Ayres , Joshua T. Stecher , Michael Therien , Eric Toone , Dave Gooden , Mark Dewhirst , Joseph A. Herbert , Diane Fels , Katherine S. Hansen
IPC分类号： B32B38/00 , C09J4/00 , C09J133/08 , B41J2/175 , C08K3/00 , A61B17/00 , A61L24/06 , B32B37/12 , B32B37/18
CPC分类号： H01L24/83 , A61B17/0057 , A61L24/06 , B32B3/266 , B32B7/14 , B32B9/04 , B32B37/1284 , B32B37/18 , B32B38/0008 , B32B2037/1253 , B32B2457/00 , B32B2457/08 , B32B2457/14 , B41J2/17559 , C08K3/00 , C09J4/00 , C09J9/02 , C09J11/04 , C09J11/06 , C09J133/08 , C09K11/02 , C09K11/7769 , C09K11/777 , H01L23/5226 , H01L24/32 , H01L25/0657 , H01L25/50 , H01L2224/16225 , H01L2224/32225 , H01L2224/48091 , H01L2224/48227 , H01L2224/73204 , H01L2224/73253 , H01L2224/73265 , H01L2224/83192 , H01L2224/83855 , H01L2224/92125 , H01L2225/06524 , H01L2225/06589 , H01L2924/07811 , H01L2924/1461 , H01L2924/15311 , Y10T428/2852 , H01L2924/00014 , H01L2924/00
摘要： A polymerizable composition includes at least one monomer, a photoinitiator capable of initiating polymerization of the monomer when exposed to light, and a phosphor capable of producing light when exposed to radiation (typically X-rays). The material is particularly suitable for bonding components at ambient temperature in situations where the bond joint is not accessible to an external light source. An associated method includes: placing a polymerizable adhesive composition, including a photoinitiator and energy converting material, such as a down-converting phosphor, in contact with at least two components to be bonded to form an assembly; and, irradiating the assembly with radiation at a first wavelength, capable of conversion (down-conversion by the phosphor) to a second wavelength capable of activating the photoinitiator, to prepare items such as inkjet cartridges, wafer-to-wafer assemblies, semiconductors, integrated circuits, and the like.
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公开(公告)号：US09526913B2
公开(公告)日：2016-12-27
申请号：US14168795
申请日：2014-01-30
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Tuan Vo-Dinh , Jonathan P. Scaffidi , Venkata Gopal Reddy Chada , Benoit Lauly , Yan Zhang , Molly K. Gregas , Ian Nicholas Stanton , Joshua T. Stecher , Michael J. Therien , Frederic A. Bourke, Jr. , Harold Walder , Zak Fathi , Jennifer A. Ayres , Zhenyuan Zhang , Joseph H. Simmons , Stephen John Norton
CPC分类号： A61N5/062 , A61B5/0059 , A61B5/0071 , A61B5/055 , A61B5/4848 , A61B6/481 , A61K41/0042 , A61K41/0052 , A61K41/0061 , A61K49/0039 , A61L2/0047 , A61L2/08 , A61L2202/21 , A61L2202/22 , A61M5/007 , A61N1/406 , A61N5/02 , A61N5/0601 , A61N5/0618 , A61N5/0622 , A61N5/0624 , A61N5/10 , A61N2005/063 , A61N2005/0656 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , A61N2005/1098
摘要： A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light, and a metallic structure attached to the phosphorescent material. The metallic structure has a surface plasmon resonance which resonates at a frequency which spectrally overlaps with one or more frequencies of the emitted light.
摘要翻译： 一种用于增强介质内发射光的基于纳米颗粒的系统。 基于纳米颗粒的系统包括磷光材料，其在激活时产生发射的光，以及附着到磷光材料的金属结构。 金属结构具有表面等离子体共振，其以与所发射的光的一个或多个频率光谱重叠的频率谐振。
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公开(公告)号：US09278331B2
公开(公告)日：2016-03-08
申请号：US14635677
申请日：2015-03-02
申请人： IMMUNOLIGHT, LLC.
IPC分类号： B01J19/12
CPC分类号： A61N5/10 , A23L2/50 , A23L3/26 , A23L3/263 , A23L3/28 , A23L5/32 , A23V2002/00 , A61K41/0057 , A61K41/0066 , A61L2/0011 , A61L2/0047 , A61L2/0076 , A61L2/082 , A61L2/088 , A61L2/10 , A61L2/16 , A61L2202/21 , A61L2202/22 , A61M1/3683 , A61N5/062 , A61N5/0624 , A61N2005/0661 , A61N2005/0662 , A61N2005/1087 , A61N2005/1089 , A61N2005/1098 , B01J19/082 , B01J19/085 , B01J19/12 , B01J19/123 , B01J19/125 , B01J19/127 , B01J19/128 , B01J23/50 , B01J23/52 , B01J31/0275 , B01J31/2295 , B01J35/0006 , B01J35/0013 , B01J35/004 , B01J37/0072 , B01J37/0221 , B01J2219/0877 , B01J2219/0879 , B01J2219/0892 , B01J2219/1203 , B01J2231/005 , B01J2531/005 , B01J2531/008 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C02F1/30 , C02F1/302 , C02F1/305 , C02F1/307 , C02F1/32 , C02F1/725 , C02F2305/10 , C08J3/24 , C08J3/28 , C08J7/18 , C08J2300/00 , C09D201/00 , C09J5/00 , C09J201/00 , C09J2205/31 , C12H1/06 , G02B5/008 , G21K5/00 , Y02W10/37 , Y10S977/774 , Y10S977/777 , Y10S977/896 , Y10S977/915 , Y10T156/10
摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.
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24.发明授权公开(公告)号：US09005406B2
公开(公告)日：2015-04-14
申请号：US14157039
申请日：2014-01-16
申请人： Immunolight, LLC.
IPC分类号： B01J19/12 , B01J19/08 , A61N5/06 , A23L3/26 , A61L2/00 , C02F1/30 , C02F1/72 , A61L2/08 , A61L2/10 , A61L2/16 , C08J3/28 , G21K5/00 , A23L1/025 , C02F1/32 , A61K41/00 , A61N5/10 , B82Y20/00
CPC分类号： A61N5/10 , A23L2/50 , A23L3/26 , A23L3/263 , A23L3/28 , A23L5/32 , A23V2002/00 , A61K41/0057 , A61K41/0066 , A61L2/0011 , A61L2/0047 , A61L2/0076 , A61L2/082 , A61L2/088 , A61L2/10 , A61L2/16 , A61L2202/21 , A61L2202/22 , A61M1/3683 , A61N5/062 , A61N5/0624 , A61N2005/0661 , A61N2005/0662 , A61N2005/1087 , A61N2005/1089 , A61N2005/1098 , B01J19/082 , B01J19/085 , B01J19/12 , B01J19/123 , B01J19/125 , B01J19/127 , B01J19/128 , B01J23/50 , B01J23/52 , B01J31/0275 , B01J31/2295 , B01J35/0006 , B01J35/0013 , B01J35/004 , B01J37/0072 , B01J37/0221 , B01J2219/0877 , B01J2219/0879 , B01J2219/0892 , B01J2219/1203 , B01J2231/005 , B01J2531/005 , B01J2531/008 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C02F1/30 , C02F1/302 , C02F1/305 , C02F1/307 , C02F1/32 , C02F1/725 , C02F2305/10 , C08J3/24 , C08J3/28 , C08J7/18 , C08J2300/00 , C09D201/00 , C09J5/00 , C09J201/00 , C09J2205/31 , C12H1/06 , G02B5/008 , G21K5/00 , Y02W10/37 , Y10S977/774 , Y10S977/777 , Y10S977/896 , Y10S977/915 , Y10T156/10
摘要： A method and a system for producing a change in a medium. The method places in a vicinity of the medium at least one energy modulation agent. The method applies an initiation energy to the medium. The initiation energy interacts with the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the energy modulation agent.
摘要翻译： 一种用于产生介质变化的方法和系统。 该方法在介质附近放置至少一种能量调节剂。 该方法对介质施加引发能量。 引发能与能量调节剂相互作用直接或间接产生介质中的变化。 该系统包括引发能量源，其被配置为向介质施加引发能量以激活能量调节剂。
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公开(公告)号：US12076579B2
公开(公告)日：2024-09-03
申请号：US17433768
申请日：2020-02-27
申请人： IMMUNOLIGHT, LLC
发明人： Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Wayne F. Beyer , Ronald A. Rudder , Joseph H. Simmons
IPC分类号： A61N5/06 , A61K35/12 , A61K41/00 , A61N5/067 , C09J133/08 , C09K11/02 , C09K11/59 , C09K11/76 , C09K11/77 , C12N15/01 , F21K2/00 , F21S11/00 , F21V9/40 , H01J45/00 , H01L23/00 , H01L31/0352 , H01L31/054 , H01L31/055 , H01L31/06
CPC分类号： A61N5/0625 , A61K35/12 , A61K41/00 , A61K41/0057 , A61N5/0601 , A61N5/062 , A61N5/067 , C09J133/08 , C09K11/025 , C09K11/595 , C09K11/76 , C09K11/7701 , C09K11/7792 , C12N15/01 , F21K2/00 , F21S11/007 , F21V9/40 , H01J45/00 , H01L24/29 , H01L24/83 , H01L31/035281 , H01L31/054 , H01L31/06 , A61N2005/0661 , A61N2005/0662 , A61N2005/0663 , H01L31/055 , H01L2224/2919 , H01L2224/29393 , H01L2224/8322 , H01L2224/83855
摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, including various adhesives applications.
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公开(公告)号：US11992697B2
公开(公告)日：2024-05-28
申请号：US17655683
申请日：2022-03-21
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Mark Oldham , Zakaryae Fathi , Wayne F. Beyer , Frederic A. Bourke, Jr. , Harold Walder , Mark Dewhirst , Neil L. Spector , Paul Yoon , Justus Adamson , David Alcorta , Kim Lyerly , Leihua Liu , Takuya Osada
IPC分类号： A61N5/06 , A61K31/352 , A61K41/00 , A61N5/10
CPC分类号： A61N5/062 , A61K31/352 , A61K41/0066 , A61N2005/0661 , A61N2005/0662 , A61N5/10 , A61N2005/1089 , A61N2005/1098
摘要： A method for treating a diseased site in a human or animal body is provided which includes injecting in a diseased site one or more phosphors which are capable of emitting ultraviolet or visible light into the body;
infusing the diseased site with a photoactivatable drug;
applying an initiation energy from an initiation energy source comprising an x-ray, gamma ray, or electron source to thereby initiate emission of ultraviolet or visible light into the body; and
controlling a dose of the initiation energy with a processor to produce (i) a cytotoxicity inside the diseased site of greater than 20% or (ii) a day-25 stable tumor volume,
wherein the processor is programmed to apply the initiation energy in a pulsed manner, wherein the initiation energy is delivered in either (i) a radiograph mode, or (ii) a pulsed fluoroscopy mode.-
公开(公告)号：US11964167B2
公开(公告)日：2024-04-23
申请号：US17433748
申请日：2020-01-30
申请人： IMMUNOLIGHT, LLC
发明人： Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Wayne F. Beyer , Ronald A. Rudder , Joseph H. Simmons
IPC分类号： A61N5/06 , A61K35/12 , A61K41/00 , A61N5/067 , C09J133/08 , C09K11/02 , C09K11/59 , C09K11/76 , C09K11/77 , C12N15/01 , F21K2/00 , F21S11/00 , F21V9/40 , H01J45/00 , H01L23/00 , H01L31/0352 , H01L31/054 , H01L31/06 , H01L31/055
CPC分类号： A61N5/0625 , A61K35/12 , A61K41/00 , A61K41/0057 , A61N5/0601 , A61N5/062 , A61N5/067 , C09J133/08 , C09K11/025 , C09K11/595 , C09K11/76 , C09K11/7701 , C09K11/7792 , C12N15/01 , F21K2/00 , F21S11/007 , F21V9/40 , H01J45/00 , H01L24/29 , H01L24/83 , H01L31/035281 , H01L31/054 , H01L31/06 , A61N2005/0661 , A61N2005/0662 , A61N2005/0663 , H01L31/055 , H01L2224/2919 , H01L2224/29393 , H01L2224/8322 , H01L2224/83855
摘要： An emission enhancement structure having at least one energy augmentation structure; and an energy converter capable of receiving energy from an energy source, converting the energy and emitting therefrom a light of a different energy than the received energy. The energy converter is disposed in a vicinity of the at least one energy augmentation structure such that the emitted light is emitted with an intensity larger than if the converter were remote from the at least one energy augmentation structure. Also described are various uses for the energy emitters, energy augmentation structures and energy collectors in a wide array of fields, such as color enhancement, and color enhancement structures containing the same.
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公开(公告)号：US11833367B2
公开(公告)日：2023-12-05
申请号：US16599732
申请日：2019-10-11
申请人： IMMUNOLIGHT, LLC.
发明人： Frederic A. Bourke, Jr. , Harold Walder , Zakaryae Fathi , Wayne F. Beyer, Jr. , Ronald A. Rudder
CPC分类号： A61N5/062 , A61K41/0057 , A61K49/0015 , A61N5/025 , A61N5/0622 , A61N5/10 , A61N2005/0661
摘要： Methods of treating a subject are provided, involving providing a first region of biological material coupled to the subject; initiating a change in a cellular environment of the cells in the first region; and due to a change in biological or chemical activity of the cells in the first region, inducing a biological change in a second region inside the subject, along with various biophoton collectors and biophoton bypasses useful for implementing a variety of the method embodiments.
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公开(公告)号：US11786595B2
公开(公告)日：2023-10-17
申请号：US17227753
申请日：2021-04-12
申请人： IMMUNOLIGHT, LLC , DUKE UNIVERSITY
发明人： Mark Oldham , Justus Adamson , Mark W. Dewhirst , Paul Yoon , Harold Walder , Frederic A. Bourke, Jr. , Zakaryae Fathi , Wayne F. Beyer, Jr.
IPC分类号： A61K41/00 , A61N5/06 , A61K31/655 , A61K33/02 , A61K31/409 , A61K31/525 , A61K31/352 , A61K31/403 , A61K33/242 , A61K33/244 , A61K33/24 , A61N5/10 , A61K31/426 , A61K31/47 , B82Y5/00
CPC分类号： A61K41/0066 , A61K31/352 , A61K31/403 , A61K31/409 , A61K31/525 , A61K31/655 , A61K33/02 , A61K33/24 , A61K33/242 , A61K33/244 , A61N5/062 , A61N5/0624 , A61N5/10 , A61K31/426 , A61K31/47 , A61K2300/00 , A61N2005/065 , A61N2005/1095 , A61N2005/1098 , B82Y5/00 , Y02A50/30
摘要： A method and system for treating a subject with a disorder which provides within the subject at least one photoactivatable drug for treatment of the subject, applies initiation energy from at least one source to generate inside the subject a preferential x-ray flux for generation of Cherenkov radiation (CR) light capable of activating at least one photoactivatable drug, and from the CR light, activating inside the subject the at least one photoactivatable drug to thereby treat the disorder.
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公开(公告)号：US11589432B2
公开(公告)日：2023-02-21
申请号：US16012901
申请日：2018-06-20
申请人： IMMUNOLIGHT, LLC. , DUKE UNIVERSITY
发明人： Frederic A. Bourke, Jr. , Zakaryae Fathi , Ian Nicholas Stanton , Michael J. Therien , Paul Rath Stauffer , Paolo Maccarini , Katherine Sarah Hansen , Diane Renee Fels , Cory Robert Wyatt
摘要： Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the upconverter being configured, upon exposure to initiation energy, to generate light for emission into the medium, and (2) apply the initiation energy from an energy source including the first wavelength λ1 to the medium, wherein the emitted light directly or indirectly produces the change in the medium. A second method and system (1) place in a vicinity of the medium an agent receptive to microwave radiation or radiofrequency radiation, and (2) apply as an initiation energy the microwave radiation or radiofrequency radiation by which the agent directly or indirectly generates emitted light in the infrared, visible, or ultraviolet range to produce at least one of physical and biological changes in the medium.
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