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    Electroactive surface-confinable molecules
    81.
    发明申请
    Electroactive surface-confinable molecules 审中-公开
    电活性表面可聚合分子

    公开(公告)号：US20050186635A1

    公开(公告)日：2005-08-25

    申请号：US10913150

    申请日：2004-08-06

    Applicant: Cynthia Bamdad ,  Shoshana Shendelman ,  Michael Frid

    Inventor： Cynthia Bamdad ,  Shoshana Shendelman ,  Michael Frid

    IPC: G01N27/48 ,  C07D213/32 ,  C07F17/02 ,  G01N27/416 ,  G01N33/58 ,  G01N33/53 ,  C12Q1/26 ,  G01N33/567

    CPC classification number: B82Y15/00 ,  B82Y30/00 ,  C07F17/02 ,  G01N33/582 ,  G01N2800/52

    Abstract: The invention provides compositions, kits, methods, and species that include electroactive entities which can serve as signaling entities in chemical and/or biochemical assays. The electroactive species can be metallocenes, such as ferrocenes, including substituents that affect the oxidation/reduction potential (redox potential) of the species. By controlling the redox potential of the species, multiple species can be used in a single assay, each species having a different redox potential, for simultaneous signaling of different binding events. Additionally, species having redox potentials lower than 490 mV can be provided, allowing signaling within a potential range easily detectable in the presence of biological fluids.

    Abstract translation: 本发明提供组合物，试剂盒，方法和物种，其包括可用作化学和/或生物化学测定中的信号实体的电活性实体。 电活性物质可以是茂金属，例如二茂铁，包括影响物质的氧化/还原电位（氧化还原电位）的取代基。 通过控制物种的氧化还原电位，可以在单个测定中使用多种物质，每种物质具有不同的氧化还原电位，用于同时发信号通知不同的结合事件。 另外，可以提供具有低于490mV的氧化还原电位的物质，使得在生物流体存在下容易检测到的潜在范围内的信号传导。

    Functionalized metal complexes
    82.
    发明授权
    Functionalized metal complexes 失效
    官能化金属络合物

    公开(公告)号：US06933399B2

    公开(公告)日：2005-08-23

    申请号：US10429206

    申请日：2003-05-02

    Applicant: Ulrich T. Mueller-Westerhoff ,  Richard W. Sanders

    Inventor： Ulrich T. Mueller-Westerhoff ,  Richard W. Sanders

    IPC: C07C323/29 ,  C07F15/04 ,  C07F17/02 ,  C07F15/00 ,  C07F19/00

    CPC classification number: C07C323/29 ,  C07F15/045 ,  C07F17/02

    Abstract: Described herein are metal complexes having the formula wherein M is nickel, palladium, or platinum; Q1-Q4 are each independently sulfur, selenium, or tellurium; X1-X4 are each independently a divalent linking group having 1 to about 125 carbons; m1 to m4 are each independently 0 or 1; and W1-W4 are each independently hydrogen, carboxylic acid, carboxylic acid anhydride, carboxylic acid chloride, sulfonic acid, or sulfonyl chloride, with the proviso that W1-W4 are not all hydrogen. The complexes have strong absorptions in the near infrared.

    Abstract translation: 本文描述的是具有下式的金属络合物：其中M是镍，钯或铂; Q 1至4 4各自独立地为硫，硒或碲; X 1〜X 4各自独立地为具有1〜约125个碳的二价连接基团; m1〜m4各自独立地为0或1; 和W 1 -W 4各自独立地为氢，羧酸，羧酸酐，羧酸酰氯，磺酸或磺酰氯，条件是W 1 -W 4不是全部是氢。 复合物在近红外线具有很强的吸收。

    Preparation of aminophosphines
    85.
    发明授权
    Preparation of aminophosphines 失效
    制备氨基膦

    公开(公告)号：US06906213B1

    公开(公告)日：2005-06-14

    申请号：US10876492

    申请日：2004-06-25

    Applicant: Neil Warren Boaz

    Inventor： Neil Warren Boaz

    IPC: B01J31/18 ,  B01J31/22 ,  C07C51/36 ,  C07C231/18 ,  C07C269/06 ,  C07F9/6571 ,  C07F17/00 ,  C07F17/02 ,  B01J31/00

    CPC classification number: C07F17/00 ,  B01J31/2295 ,  B01J31/2495 ,  B01J2231/323 ,  B01J2231/44 ,  B01J2231/52 ,  B01J2231/645 ,  B01J2531/822 ,  B01J2531/842 ,  C07C51/36 ,  C07C231/18 ,  C07C269/06 ,  C07F9/657154 ,  C07F17/02 ,  C07C55/02

    Abstract: Disclosed is a process for the preparation of phosphine-aminophosphines that are useful in the formation of catalysts useful in carrying out a wide variety of reactions such as asymmetric hydrogenations, asymmetric reductions, asymmetric hydroborations, asymmetric olefin isomerizations, asymmetric hydrosilations, asymmetric allylations, asymmetric conjugate additions, and asymmetric organometallic additions. The process comprises the steps of (1) contacting a compound of formula 2 R2P—L—NHR3  2 with phosphorus trihalide PX3 in the presence of an inert, organic solvent and an acid acceptor to produce intermediate compound having formula 3 (2) contacting intermediate compound 3 with a reactant having the formula R1—M1, R2—M1 or a mixture thereof.

    Abstract translation: 公开了一种制备膦 - 氨基膦的方法，其可用于形成可用于进行各种各样的反应的催化剂，例如不对称氢化，不对称还原，不对称氢化，不对称烯烃异构化，不对称氢化硅，不对称烯丙基化，不对称烯丙基化 共轭添加物和不对称有机金属添加剂。 该方法包括以下步骤：（1）使式2的化合物<？in-line-formula description =“In-Line Formulas”end =“lead”→> R 2 PL-NHR < 在惰性有机物的存在下，使用三卤代磷酸酯PX 3将“3”在线式描述=“In-line Formula”end =“tail”？> 溶剂和酸受体以产生具有式3（2）的中间体化合物，使中间体化合物3与具有式R 1，M 2，R 2， 或其混合物。

    Bi-functionalised metallocenes use for marking biological molecules
    90.
    发明申请
    Bi-functionalised metallocenes use for marking biological molecules 失效
    双功能金属茂用于标记生物分子

    公开(公告)号：US20050038234A1

    公开(公告)日：2005-02-17

    申请号：US10501347

    申请日：2003-02-14

    Applicant: Carole Chaix-Bauvais ,  Corinne Moustrou ,  Aude-Emmanuelle Navarro ,  Hugues Brisset ,  Francis Garnier ,  Bernard Mandrand ,  Nicolas Spinelli

    Inventor： Carole Chaix-Bauvais ,  Corinne Moustrou ,  Aude-Emmanuelle Navarro ,  Hugues Brisset ,  Francis Garnier ,  Bernard Mandrand ,  Nicolas Spinelli

    IPC: C12N15/00 ,  A61K49/00 ,  C07F17/00 ,  C07F17/02 ,  C07H21/04 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K1/00

    CPC classification number: C07F17/02 ,  Y02P20/55

    Abstract: The invention relates to bi-functionalised metallocenes of general formula (I) where Me=a transition metal, preferably chosen from Fe, Ru and Os, Y and Z, when identical are selected from —(CH2)n—O—, (CH2)—O—[(CH2)2—O]P— and —(CH2)q—CONH—(CH2)r—O—, or Y=—(CH2)S—NH— and Z=—(CH2)t—COO—, n=a whole number from 3 to 6 inclusive, p=a whole number from 1 to 4 inclusive, q=a whole number from 0 to 2 inclusive, r=a whole number from 0 to 2 inclusive, s=a whole number from 2 to 5 inclusive, t=a whole number from 3 to 6 inclusive, R and R′=H atoms or are protective groups used in oligonucleotide and peptide synthesis, where at least one of R or R′ is protective group used in oligonucleotide and peptide synthesis and R and R′ are as defined below: (i) when Z and Y are selected from (CH2)n—O—, —(CH2)—O—[(CH2)2—O]p— and —(CH2)q—CONH—(CH2)r—O—, then R and R′ are protective groups used in oligonucleotide synthesis and R is a group which can leave a free OH group after deprotection, preferably a photolabile group such as monomethroxythoxytrityl, dimethoxytrityl, t-butyldimethylsilyl, acetyl or trifluroacetyl, and R′ is a phosphorylated group which can react with a free OH, preferably a phosphodiester, phosphoramidite or H-phosphonate and (ii) when Y=—(CH2)n—NH— and Z=—(CH2)t—COO—, then R is a protective group used in the synthesis of peptides and is an amino-protecting group, preferably 9-fluorenyloxycarbonyl, t-butoxycarbonyl or benzyloxycarbonyl and R′=H. The above is applied in marking.

    Abstract translation: 本发明涉及通式（I）的双官能化金属茂，其中Me =过渡金属，优选选自Fe，Ru和Os，Y和Z，当相同时，选自 - （CH 2）n O-，（CH 2） O - [（CH 2）2 -O] P - 和 - （CH 2）q -CONH-（CH 2）r O-或Y = - （CH 2）S -NH-和Z = - （CH 2）t -COO-， n =从3到6的整数，p =从1到4的整数，q =从0到2的整数，包括0和2，r =从0到2的整数，s =从 2〜5，t = 3〜6的整数，R和R'= H原子，或者是寡核苷酸和肽合成中使用的保护基，其中R或R'中的至少一个为寡核苷酸中使用的保护基， 肽合成和R和R'定义如下：（i）当Z和Y选自（CH 2）n O-， - （CH 2）-O - [（CH 2）2 -O] p - 和 - （CH 2） q-CONH-（CH 2）r O - ，则R和R'是寡核苷酸合成中使用的保护基，R是在去保护后可以留下游离OH基团的基团， 顺式基团如单甲氧基三苯甲基，二甲氧基三苯甲基，叔丁基二甲基甲硅烷基，乙酰基或三氟乙酰基，R'是可以与游离OH，优选磷酸二酯，亚磷酰胺或H-膦酸酯反应的磷酸化基团，和（ii）当Y = - （CH2 ）n-NH-和Z = - （CH2）t-COO-，则R是用于合成肽的保护基，并且是氨基保护基，优选9-氟芳氧基羰基，叔丁氧基羰基或苄氧基羰基和R' = H。 上述适用于标记。

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