Systems and method for detecting cognitive impairment

    公开(公告)号:US11963786B2

    公开(公告)日:2024-04-23

    申请号:US17298925

    申请日:2019-12-06

    发明人: Delia DeBuc

    IPC分类号: A61B5/00 A61B3/12 A61B5/398

    摘要: Systems, methods, and computer readable media for determining cognitive impairment (CI) in patients are provided herein. Various regional structural-functional parameters of the retina can serve as biomarkers for the detection of CI. The method can include forming a database including a quantification of retinal structure and retinal function of a plurality of eyes associated with a plurality of patients, providing a baseline cognitive impairment (CI) reference. The method can include determining a measure of functionality of neurons in the retina based on an electroretinogram (ERG) of a patient. The method can include determining a structural measure of the first retina based on a generalized dimension spectrum and singularity spectrum of the skeletonized retinal image, and a lacunarity parameter of the skeletonized retinal image. The method can include determining a level of cognitive impairment based on the structural and functional measures.