公开(公告)号：US20190153531A1

公开(公告)日：2019-05-23

申请号：US15974364

申请日：2018-05-08

Applicant: Ultima Genomics, Inc.

Inventor： Kristopher BARBEE ,  Nathan BECKETT ,  Denis PRISTINSKI ,  Derek SCHULTE ,  Avishai BARTOV ,  Jamie SULLIVAN ,  Dumitru BRINZA ,  Abizar LAKDAWALLA ,  Steven MENCHEN ,  Gilad ALMOGY ,  Mark PRATT

IPC: C12Q1/6874 ,  C12Q1/6825

CPC classification number: C12Q1/6874 ,  B01J19/0046 ,  B01J2219/00536 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01L3/5023 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/026 ,  B01L2200/0647 ,  B01L2300/0654 ,  B01L2400/0409 ,  C12Q1/6809 ,  C12Q1/6825 ,  C12Q1/6834 ,  G01N33/54366 ,  C12Q2565/629

Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.

公开(公告)号：US10001478B2

公开(公告)日：2018-06-19

申请号：US14904764

申请日：2014-08-14

Applicant: MYCARTIS NV

Inventor： Raphael Tornay ,  Patrick Van Den Bogaard ,  Nicolas Demierre ,  Didier Falconnet

IPC: G01N21/75 ,  G01N33/543 ,  B01L3/00

CPC classification number: G01N33/54386 ,  B01J2219/00536 ,  B01J2219/00556 ,  B01J2219/0056 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00693 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/021 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0832

Abstract: The present invention relates to a microcarrier comprising at least a detection surface for performing an assay, said detection surface comprising a first area being functionalized with a first functional group for detecting at least a chemical and/or biological interaction, said first area being designed for providing a first signal. The microcarrier is characterized in that the detection surface further comprises a second area being designed for providing a second signal different from the first signal, said second signal being emitted during the assay. Thus, information about the presence of the at least a chemical and/or biological interaction is provided by a comparison of the first signal and the second signal.

公开(公告)号：US09206477B2

公开(公告)日：2015-12-08

申请号：US14513906

申请日：2014-10-14

Applicant: Cornell Research Foundation, Inc.

Inventor： Francis Barany ,  George Barany ,  Robert P. Hammer ,  Maria Kempe ,  Herman Blok ,  Monib Zirvi

IPC: C07H21/04 ,  C12N15/11 ,  C12Q1/68 ,  B01J19/00 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14

CPC classification number: C12Q1/6827 ,  B01J19/0046 ,  B01J2219/00432 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00729 ,  B82Y30/00 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q1/6876 ,  C12Q2600/156 ,  C40B40/06 ,  C40B60/14 ,  Y02A50/58 ,  C12Q2565/501 ,  C12Q2561/125 ,  C12Q2537/143 ,  C12Q2565/514

Abstract: The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support.

Abstract translation: 本发明描述了用于鉴定多个靶核苷酸序列中一个或多个单碱基变化，插入，缺失或易位不同的多个序列中的一个或多个的方法。 该方法包括连接阶段，捕获阶段和检测阶段。 连接阶段利用具有目标序列特异性部分的一个寡核苷酸探针与可寻址阵列特异性部分之间的连接检测反应和具有靶序列特异性部分和可检测标记的第二寡核苷酸探针。 在连接阶段之后，捕获阶段通过将连接的寡核苷酸探针与具有固定化捕获寡核苷酸阵列的固体支持物杂交进行，其中至少一些与可寻址阵列特异性部分互补。 捕获阶段完成后，进行检测阶段以检测与固体支持物杂交的连接的寡核苷酸探针的标记。

公开(公告)号：US20150224482A1

公开(公告)日：2015-08-13

申请号：US14692495

申请日：2015-04-21

Applicant: Siluria Technologies, Inc.

Inventor： Joel M. Cizeron ,  Erik C. Scher ,  Fabio R. Zurcher ,  Wayne P. Schammel ,  Greg Nyce ,  Anja Rumplecker ,  Jarod McCormick ,  Marian Alcid ,  Joel Gamoras ,  Daniel Rosenberg ,  Erik-Jan Ras

IPC: B01J23/889 ,  B01J23/34 ,  B01J27/16 ,  B01J21/06 ,  B01J35/00 ,  B01J23/10 ,  B01J21/08

CPC classification number: C07C2/84 ,  B01J19/0046 ,  B01J21/066 ,  B01J21/08 ,  B01J23/002 ,  B01J23/10 ,  B01J23/34 ,  B01J23/54 ,  B01J23/63 ,  B01J23/76 ,  B01J23/83 ,  B01J23/8892 ,  B01J27/16 ,  B01J35/0006 ,  B01J37/031 ,  B01J37/035 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00702 ,  B01J2219/00747 ,  B01J2523/00 ,  C07C2521/10 ,  C07C2521/14 ,  C07C2523/10 ,  C07C2523/18 ,  C07C2523/34 ,  C07C2529/072 ,  C07C2529/076 ,  C07C2529/89 ,  Y02P20/52 ,  B01J2523/24 ,  B01J2523/3706 ,  B01J2523/3725 ,  B01J2523/3712 ,  B01J2523/54 ,  B01J2523/23 ,  B01J2523/11 ,  B01J2523/22 ,  B01J2523/305 ,  B01J2523/72 ,  B01J2523/845 ,  B01J2523/12 ,  B01J2523/69 ,  C07C11/04

Abstract: Metal oxide catalysts comprising various dopants are provided. The catalysts are useful as heterogenous catalysts in a variety of catalytic reactions, for example, the oxidative coupling of methane to C2 hydrocarbons such as ethane and ethylene. Related methods for use and manufacture of the same are also disclosed.

公开(公告)号：US09016233B1

公开(公告)日：2015-04-28

申请号：US12108456

申请日：2008-04-23

Applicant: Kurt Weiner ,  Aaron Francis ,  John Schmidt

Inventor： Kurt Weiner ,  Aaron Francis ,  John Schmidt

IPC: B05C3/20 ,  H01L21/67 ,  C23C16/458 ,  C23C16/455

CPC classification number: C23C16/45502 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00313 ,  B01J2219/00337 ,  B01J2219/00389 ,  B01J2219/00481 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00612 ,  B01J2219/00745 ,  B05C3/20 ,  C23C18/00 ,  H01L21/67017 ,  H01L21/6719 ,  Y10T137/4673

Abstract: A reactor assembly having vertically adjustable flow cells is provided. The vertically adjustable flow cells include passageways for distributing a fluid to a reaction region isolated below a bottom surface of corresponding flow cells. The adjustable flow cells enable another dimension of variability for combinatorial processing. Thus, additional data may be gathered for effects on process parameter variations, material variations, process sequence variations, etc., for semiconductor processing operations.

Abstract translation: 提供具有垂直可调流动池的反应器组件。 垂直可调的流动池包括用于将流体分配到分离在相应流动池的底表面下方的反应区域的通道。 可调整的流通池可实现组合处理的另一个可变性尺寸。 因此，可以收集关于半导体处理操作的过程参数变化，材料变化，过程序列变化等的影响的附加数据。

公开(公告)号：US08709270B2

公开(公告)日：2014-04-29

申请号：US13324818

申请日：2011-12-13

Applicant: Peter Satitpunwaycha

Inventor： Peter Satitpunwaycha

IPC: H01J37/32 ,  H01L21/31 ,  H01L21/311

CPC classification number: H01J37/32623 ,  B01J19/0046 ,  B01J2219/0043 ,  B01J2219/00536 ,  B01J2219/00596 ,  B01J2219/00756 ,  C23C14/042 ,  C23C14/351 ,  C23C14/352 ,  C40B60/14 ,  H01J37/321 ,  H01L21/31116

Abstract: A chamber for combinatorially processing a substrate is provided. The chamber includes a first mask and a second mask that share a common central axis. The first mask and the second mask are independently rotatable around the common central axis. The first mask has a first plurality of radial apertures and the second mask has a second plurality of radial apertures. An axis of the first plurality of radial apertures is offset from an axis of the second plurality of radial apertures. A substrate support that is operable to support a substrate below the first and second masks is included. The substrate support shares the common central axis.

Abstract translation: 提供了用于组合处理衬底的腔室。 腔室包括共享公共中心轴的第一掩模和第二掩模。 第一掩模和第二掩模可以围绕公共中心轴独立地旋转。 第一掩模具有第一多个径向孔，并且第二掩模具有第二多个径向孔。 第一多个径向孔的轴线偏离第二多个径向孔的轴线。 包括可操作以支撑第一和第二掩模下面的衬底的衬底支撑件。 基板支架共用共同的中心轴。

公开(公告)号：US08630807B2

公开(公告)日：2014-01-14

申请号：US11401713

申请日：2006-04-11

Applicant: Carl F. Edman ,  Michael J. Heller ,  Rachel Formosa ,  Christian Gurtner

Inventor： Carl F. Edman ,  Michael J. Heller ,  Rachel Formosa ,  Christian Gurtner

IPC: G01N33/50 ,  G01N33/48

CPC classification number: H01L24/95 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00536 ,  B01J2219/00545 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00614 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00707 ,  B01J2219/00711 ,  B01J2219/00713 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L9/52 ,  B01L2200/025 ,  B01L2200/028 ,  B01L2200/12 ,  B01L2300/0819 ,  B01L2400/0418 ,  B82B3/00 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C07B2200/11 ,  C07H21/00 ,  C07K1/04 ,  C07K1/045 ,  C07K1/047 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  C40B70/00 ,  G01N33/54366 ,  G02B6/1225 ,  G06N3/002 ,  G06N3/061 ,  G06N3/123 ,  G11B7/00455 ,  G11B7/0052 ,  G11B7/244 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/04 ,  G11C19/00 ,  H01L25/50 ,  H01L29/6656 ,  H01L29/6659 ,  H01L29/66628 ,  H01L29/7834 ,  H01L51/0093 ,  H01L51/0595 ,  H01L2224/95085 ,  H01L2224/95145 ,  H01L2224/95147 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01011 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01018 ,  H01L2924/01019 ,  H01L2924/0102 ,  H01L2924/01023 ,  H01L2924/01027 ,  H01L2924/01033 ,  H01L2924/01039 ,  H01L2924/01044 ,  H01L2924/01047 ,  H01L2924/01049 ,  H01L2924/01052 ,  H01L2924/01072 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/01322 ,  H01L2924/014 ,  H01L2924/10253 ,  H01L2924/10329 ,  H01L2924/12041 ,  H01L2924/12042 ,  H01L2924/14 ,  H01L2924/1461 ,  H01L2924/30105 ,  H01L2924/3025 ,  H01L2924/00

Abstract: Methods are provided for the fabrication of microscale, including micron and sub-micron scale, including nanoscale, devices. Electronic transport of movable component devices is utilized through a fluidic medium to effect transport to a desired target location on a substrate or motherboard. Forces include electrophoretic force, electroosmotic force, electrostatic force and/or dielectrophoretic force. In the preferred embodiment, free field electroosmotic forces are utilized either alone, or in conjunction with, other forces. These forces may be used singly or in combination, as well as in conjunction with yet other forces, such as fluidic forces, mechanical forces or thermal convective forces. Transport may be effected through the use of driving electrodes so as to transport the component device to yet other connection electrodes. In certain embodiments, the component devices may be attached to the target device using a solder reflow step.

Abstract translation: 提供了用于制造微尺寸的方法，包括微米级和亚微米级，包括纳米尺度的器件。 通过流体介质利用可移动部件装置的电子传输，以实现传输到基板或主板上的期望的目标位置。 力包括电泳力，电渗力，静电力和/或介电泳力。 在优选实施例中，自由场电渗力单独使用或与其它力结合使用。 这些力可以单独使用或组合使用，以及结合其他力，例如流体力，机械力或热对流力。 传输可以通过使用驱动电极来实现，以便将组件设备传送到另外的连接电极。 在某些实施例中，组件装置可以使用焊料回流步骤连接到目标装置。

公开(公告)号：US20130149868A1

公开(公告)日：2013-06-13

申请号：US13324818

申请日：2011-12-13

Applicant: Peter Satitpunwaycha

Inventor： Peter Satitpunwaycha

IPC: H01L21/3065 ,  C23F1/08 ,  C23C16/04 ,  H01L21/30

CPC classification number: H01J37/32623 ,  B01J19/0046 ,  B01J2219/0043 ,  B01J2219/00536 ,  B01J2219/00596 ,  B01J2219/00756 ,  C23C14/042 ,  C23C14/351 ,  C23C14/352 ,  C40B60/14 ,  H01J37/321 ,  H01L21/31116

Abstract: A chamber for combinatorially processing a substrate is provided. The chamber includes a first mask and a second mask that share a common central axis. The first mask and the second mask are independently rotatable around the common central axis. The first mask has a first plurality of radial apertures and the second mask has a second plurality of radial apertures. An axis of the first plurality of radial apertures is offset from an axis of the second plurality of radial apertures. A substrate support that is operable to support a substrate below the first and second masks is included. The substrate support shares the common central axis.

Abstract translation: 提供了用于组合处理衬底的腔室。 腔室包括共享公共中心轴的第一掩模和第二掩模。 第一掩模和第二掩模可以围绕公共中心轴独立地旋转。 第一掩模具有第一多个径向孔，并且第二掩模具有第二多个径向孔。 第一多个径向孔的轴线偏离第二多个径向孔的轴线。 包括可操作以支撑第一和第二掩模下面的衬底的衬底支撑件。 基板支架共用共同的中心轴。

公开(公告)号：US08449678B2

公开(公告)日：2013-05-28

申请号：US12028643

申请日：2008-02-08

Applicant: Rick Endo ,  Kurt Weiner ,  Indranil De ,  James Tsung ,  Maosheng Zhao ,  Jeremy Cheng

Inventor： Rick Endo ,  Kurt Weiner ,  Indranil De ,  James Tsung ,  Maosheng Zhao ,  Jeremy Cheng

IPC: H01L21/31 ,  C23C16/458 ,  C23C16/50 ,  B65H1/00

CPC classification number: H01L21/32051 ,  B01J19/0046 ,  B01J2219/0043 ,  B01J2219/00536 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00745 ,  B01J2219/00756 ,  C23C14/042 ,  C23C14/50 ,  C23C14/548 ,  C23C16/45544 ,  H01L21/67005 ,  H01L21/6719

Abstract: A combinatorial processing chamber is provided. The combinatorial processing chamber is configured to isolate a radial portion of a rotatable substrate support, which in turn is configured to support a substrate. The chamber includes a plurality of clusters process heads in one embodiment. An insert having a base plate disposed between the substrate support and the process heads defines a confinement region for a deposition process in one embodiment. The base plate has an opening to enable access of the deposition material to the substrate. Through rotation of the substrate and movement of the opening, multiple regions of the substrate are accessible for performing combinatorial processing on a single substrate.

公开(公告)号：US08402845B2

公开(公告)日：2013-03-26

申请号：US13596884

申请日：2012-08-28

Applicant: Jay B. Dedontney

Inventor： Jay B. Dedontney

IPC: G01N19/00 ,  G01F1/00 ,  C23F1/00 ,  H01L21/306 ,  C23C16/455 ,  C23C16/44 ,  B67D7/30 ,  C23C16/06 ,  C23C16/22

CPC classification number: C23C16/45565 ,  B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00376 ,  B01J2219/00418 ,  B01J2219/00443 ,  B01J2219/00495 ,  B01J2219/00536 ,  B01J2219/00603 ,  B01J2219/00698 ,  C23C16/45574 ,  C23C16/45578 ,  Y10T29/49764 ,  Y10T137/0318

Abstract: An apparatus for deploying two fluids separately into a reaction chamber is provided. The apparatus includes a first distribution network that is formed on a plate having a distribution face and a dispensing face. The first distribution network is defined by a plurality of recessed channels on the distribution face. The plurality of recessed channels includes a plurality of thru-ports that extend from the plurality of recessed channels to the dispensing face. The apparatus further includes a second distribution network that has passages formed below the plurality of recessed channels and above the dispensing face. A first set of ports extends from the passages to the distribution face and a second set of ports extends from a top surface of the distribution face to the dispensing face.

Abstract translation: 提供了一种用于将两种流体单独地部署到反应室中的装置。 该装置包括形成在具有分配面和分配面的板上的第一分配网络。 第一分配网络由分配面上的多个凹陷通道限定。 多个凹陷通道包括从多个凹陷通道延伸到分配面的多个通孔。 该装置还包括第二分配网络，其具有形成在多个凹陷通道下方并且在分配面上方的通道。 第一组端口从通道延伸到分配面，并且第二组端口从分配面的顶表面延伸到分配面。