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公开(公告)号：US20160090592A1
公开(公告)日：2016-03-31
申请号：US14885962
申请日：2015-10-16
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William BANYAI , Bill James PECK , Andres FERNANDEZ , Siyuan CHEN , Pierre INDERMUHLE
IPC: C12N15/10
CPC classification number: B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/00497 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00623 , B01J2219/00637 , B01J2219/00709 , B01J2219/00722 , C12N15/09 , C12N15/1093 , C12N15/1096 , C12N15/66 , C12N15/74 , C40B40/06 , C40B50/00 , C40B50/14 , C40B50/18
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US20160089651A1
公开(公告)日：2016-03-31
申请号：US14885965
申请日：2015-10-16
Applicant: TWIST BIOSCIENCE CORPORATION
Inventor： William BANYAI , Bill James PECK , Andres FERNANDEZ , Siyuan CHEN , Pierre INDERMUHLE
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00313 , B01J2219/00317 , B01J2219/00378 , B01J2219/00497 , B01J2219/00585 , B01J2219/00587 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00619 , B01J2219/00623 , B01J2219/00637 , B01J2219/00709 , B01J2219/00722 , C12N15/09 , C12N15/1093 , C12N15/1096 , C12N15/66 , C12N15/74 , C40B40/06 , C40B50/00 , C40B50/14 , C40B50/18
Abstract: De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein.
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公开(公告)号：US09297762B2
公开(公告)日：2016-03-29
申请号：US14827545
申请日：2015-08-17
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Stephen Empedocles , Andrew Watson , Jian Jin
IPC: G01N21/75 , G01N21/64 , G01N21/27 , B01L3/00 , G01N21/25 , G01N33/543 , G01N35/00 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N15/00 , G01N15/14
CPC classification number: G01N21/272 , B01J2219/00317 , B01J2219/00432 , B01J2219/005 , B01J2219/00574 , B01J2219/00576 , B01J2219/00578 , B01J2219/00585 , B01J2219/00596 , B01J2219/00648 , B01J2219/00657 , B01J2219/00659 , B01J2219/00677 , B01J2219/00707 , B01J2219/00722 , B01J2219/00743 , B01L3/5025 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L3/545 , B01L2200/0668 , B01L2300/021 , B01L2300/0819 , B01L2300/0829 , B01L2400/0454 , B01L2400/0457 , B82Y30/00 , C40B40/06 , C40B60/14 , G01N21/25 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6486 , G01N21/6489 , G01N33/54373 , G01N2015/0092 , G01N2015/1472 , G01N2015/1497 , G01N2021/6441 , G01N2021/6482 , G01N2035/00158 , G01N2035/00742 , G01N2035/00752 , G01N2201/04 , G01N2201/06113 , G01N2201/12
Abstract: Devices, systems, kits, and methods for detecting and/or identifying a plurality of spectrally labeled bodies well-suited for performing multiplexed assays. By spectrally labeling the beads with materials which generate identifiable spectra, a plurality of beads may be identified within the fluid. Reading of the beads is facilitated by restraining the beads in arrays, and/or using a focused laser.
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公开(公告)号：US20160074828A1
公开(公告)日：2016-03-17
申请号：US14713365
申请日：2015-05-15
Inventor： Tung-Tsun CHEN , Yi-Shao LIU , Jui-Cheng HUANG , Chin-Hua WEN , Felix Ying-Kit TSUI , Yung-Chow PENG
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00495 , B01J2219/00585 , B01J2219/00596 , B01J2219/00716 , B01J2219/00722
Abstract: An integrated circuit includes a plurality of sensing pixels. Each sensing pixel of the plurality of sensing pixels includes a sensing film portion, a potential-sensing device configured to generate a first signal responsive to an electrical characteristic of the sensing film portion, a temperature-sensing device configured to generate a second signal responsive to a temperature of the sensing film portion, and one or more heating elements configured to adjust the temperature of the sensing film portion.
Abstract translation: 集成电路包括多个感测像素。 多个感测像素的每个感测像素包括感测膜部分，电位感测装置，被配置为响应于感测膜部分的电特性产生第一信号;温度感测装置，被配置为产生响应于 感测膜部分的温度，以及被配置为调节感测膜部分的温度的一个或多个加热元件。
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公开(公告)号：US20160053310A1
公开(公告)日：2016-02-25
申请号：US14879932
申请日：2015-10-09
Applicant: ILLUMINA, INC.
Inventor： Min-Jui Richard Shen , Jonathan Mark Boutell , Kathryn M. Stephens , Mostafa Ronaghi , Kevin Gunderson , Bala Murali Venkatesan , M. Shane Bowen , Kandaswamy Vijayan
IPC: C12Q1/68
CPC classification number: C12Q1/6848 , B01J19/0046 , B01J2219/00585 , B01J2219/00587 , B01J2219/00608 , B01J2219/00621 , B01J2219/00637 , B01J2219/00653 , B01J2219/00675 , B01J2219/00722 , C12Q1/6844 , C12Q1/6874 , C12Q2521/507 , C12Q2527/101 , C12Q2527/113 , C12Q2535/122 , C12Q2565/513 , C12Q2565/537
Abstract: A method including (a) providing an amplification reagent including an array of sites, and a solution having different target nucleic acids; and (b) reacting the amplification reagent to produce amplification sites each having a clonal population of amplicons from a target nucleic acid from the solution. The reacting can include simultaneously transporting the nucleic acids to the sites at an average transport rate, and amplifying the nucleic acids that transport to the sites at an average amplification rate, wherein the average amplification rate exceeds the average transport rate. The reacting can include producing a first amplicon from a nucleic acid that transports to each of the sites, and producing subsequent amplicons from the nucleic acid or from the first amplicon, wherein the average rate at which the subsequent amplicons are generated exceeds the average rate at which the first amplicon is generated.
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Patent Agency Ranking
公开(公告)号：US20160051960A1
公开(公告)日：2016-02-25
申请号：US14836432
申请日：2015-08-26
Applicant: The University of Chicago
Inventor： Rustem F. Ismagilov , Joshua David Tice , Helen Song , Lewis Spencer Roach
CPC classification number: B01L3/502784 , B01F3/0861 , B01F5/0403 , B01F5/0646 , B01F5/0647 , B01F13/0071 , B01F2215/0037 , B01J19/0046 , B01J19/0093 , B01J2219/00286 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00722 , B01J2219/00725 , B01J2219/00736 , B01J2219/0074 , B01J2219/00756 , B01J2219/00783 , B01J2219/00837 , B01J2219/0086 , B01J2219/00867 , B01J2219/00869 , B01J2219/00889 , B01J2219/00891 , B01J2219/00975 , B01J2219/00977 , B01L3/502746 , B01L3/502761 , B01L7/52 , B01L2200/0647 , B01L2200/0668 , B01L2200/0673 , B01L2200/10 , B01L2300/0867 , B01L2300/0883 , B01L2400/0424 , B01L2400/0448 , B01L2400/0454 , B01L2400/0487 , B82Y30/00 , C12P19/34 , C12Q1/44 , G01N15/1404 , G01N15/1484 , G01N35/08 , G01N35/085 , G01N2015/1409 , Y02A90/26 , Y10T436/118339 , Y10T436/12 , Y10T436/2575
Abstract: The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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公开(公告)号：US09248445B2
公开(公告)日：2016-02-02
申请号：US12723557
申请日：2010-03-12
Applicant: Tadashi Okamoto , Nobuko Yamamoto , Hidenori Watanabe , Tomohiro Suzuki
Inventor： Tadashi Okamoto , Nobuko Yamamoto , Hidenori Watanabe , Tomohiro Suzuki
CPC classification number: B01L3/0268 , B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B41J2/14137 , B41J2002/1437 , B41J2002/14459 , C40B40/06 , C40B60/14
Abstract: A liquid discharging device includes a plurality of liquid discharge sections. Each liquid discharge section includes a reservoir, a nozzle that discharges a solution supplied from the reservoir, and discharge energy generating means that generates energy to discharge the solution from the nozzle. The number of the liquid discharge sections corresponds to the number of probe types to be formed. The nozzles are two-dimensionally arranged. Using this liquid discharging device, probe liquids are discharged from the corresponding reservoirs onto a solid-phase substrate to form a predetermined two-dimensional probe array of high-purity probes on the substrate. This process exhibits high reproducibility and processability, and the resulting probe array has high array density.
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公开(公告)号：US20160016140A1
公开(公告)日：2016-01-21
申请号：US14804675
申请日：2015-07-21
Applicant: Stevan B. Jovanovich , Seth Stern , Ezra Van Gelder , Mattias Vangbo
Inventor： Stevan B. Jovanovich , Seth Stern , Ezra Van Gelder , Mattias Vangbo
CPC classification number: B01J19/0046 , B01J2219/00389 , B01J2219/00599 , B01J2219/00716 , B01J2219/00722 , B01L3/502738 , B01L7/52 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2400/043 , B01L2400/0481 , B01L2400/0655 , C12Q1/6806 , C12Q1/6869 , C12Q1/6874 , F16K99/0015 , F16K99/0059 , F16K2099/0084
Abstract: The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.
Abstract translation: 本发明提供用于执行综合分析的系统，设备，方法和套件。 综合分析可以包括样品处理，库构建，扩增和测序。 集成分析可以在一个或多个流体连接的模块中进行。 一个或多个模块可以由计算机控制和/或自动化。 可以对组织样品，临床样品或环境样品进行综合分析。 集成分析系统可以具有紧凑的格式，并在指定的时间段内返回结果。
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79.发明授权公开(公告)号：US09234235B2
公开(公告)日：2016-01-12
申请号：US10902641
申请日：2004-07-29
Applicant: Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
Inventor： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
CPC classification number: C40B40/06 , B01J19/0046 , B01J2219/00599 , B01J2219/0061 , B01J2219/00612 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C12N15/1006 , C12N15/1058 , C12Q1/68 , C12Q1/6809 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/10 , G01N33/68 , C12Q2565/501 , C12Q2563/179 , C12Q2545/114 , C12Q2525/155 , C12Q2565/514 , C12Q2565/537
Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
Abstract translation: 本发明提供了用于分析物检测，定量和扩增的新型组合物和方法。 分析物的核酸阵列和文库可有效地并入到这样的组合物和方法中。 使用通用检测元件，信号实体等来检测并且如果需要或期望量化分析物。 靶分析物的扩增也由本发明的组合物和方法提供。
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公开(公告)号：US09234234B2
公开(公告)日：2016-01-12
申请号：US10900454
申请日：2004-07-27
Applicant: Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
Inventor： Elazar Rabbani , Jannis G. Stavrianopoulos , James J. Donegan , Jack Coleman
CPC classification number: C40B40/06 , B01J19/0046 , B01J2219/00599 , B01J2219/0061 , B01J2219/00612 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C12N15/1006 , C12N15/1058 , C12Q1/68 , C12Q1/6809 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/10 , G01N33/68 , C12Q2565/501 , C12Q2563/179 , C12Q2545/114 , C12Q2525/155 , C12Q2565/514 , C12Q2565/537
Abstract: This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
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